This study was conducted to investigate social integration among, and the availability of social support for, female patients with undefined musculoskeletal disorder compared to women with coronary heart disease. The aim was to elucidate the importance of a clear diagnosis for the social network relationships of these female patients. For the measurement of social support two instruments were used: an abbreviated version of the Interview Schedule for Social Interaction and a condensed version of the Interpersonal Support Evaluation List. After adjustment for age, marital and employment status, significant differences can be recognized between the two groups of patients: MSD-patients interact with fewer people and receive less emotional support. Implications for social work practice and issues for future research are presented.