The use of medical models within the Swedish healthcare is limited. One reason for this is the lack of knowledge how to sterilize them to be able to use the in an operating room. The goal of this thesis has therefore been to investigate if medical models manufactured by rapid prototyping can be sterilized by any of the methods approved by the Swedish authority Socialstyrelsen. The study has covered two different rapid prototyping methods FDM - Fused Deposition Modeling and JP - Jet Print. The two machines that were used are Stratasys Prodigy Plus (FDM) and ObJet Eden 260v (JP). The building materials that were used are P400 ABS in FDM and FullCure720 in JP. The support materials that were used are P400-SR in FDM and FullCure705 in JP. In order to avoid misconceptions with various stakeholders has a definition of what a medical model is been created. Different grades of purity has been studied and how to achieve them. In order to determine the purity of the samples before and after they have been sterilized have an environmental investigation been performed. Due to different sterilization methods can affect the material in different ways and hence its shape have a deformation study been performed. A number of reference geometries have been measured before and after they have been subjected to the sterilization process. In order not to skip any aspect and to have measurable and comparable values have an experimental plan been constructed. The conclusion to be drawn after the study is: Sterilization of FullCure720 with saturated water vapour works and the material can be considered sterile. Sterilization of P400 ABS with cold chemical sterilization also works; however, the material can only be classified as a high-purity material. The other test samples can only be classified as clean. The shape changes that have been measured are all below 0.5 mm and are therefore considered not to have any bearing on the medical model's function.