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  • 51.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Studie till grund för diskussion om spädbarnsvaccin2011Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 108, nr 15Artikkel i tidsskrift (Annet vitenskapelig)
  • 52.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Sverige måste agera för en kärnvapenfri värld 20302016Annet (Annet (populærvitenskap, debatt, mm))
  • 53.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Sämre kvalitet i vård med vinst (9 april 2013); Forskarvärlden ovanligt enig om vinst i vården (15 april 2013)2013Inngår i: Svenska dagbladet, ISSN 1101-2412Artikkel, omtale (Annet (populærvitenskap, debatt, mm))
  • 54.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Så blir vi bättre på att delta i Cochranesamarbetet2016Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, s. 113-113, artikkel-id ECW7Artikkel i tidsskrift (Annet vitenskapelig)
  • 55.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Tidig hemgång från BB: Ingen nackdel, ingen fördel2003Inngår i: Läkartidningen, ISSN 0023-7205, Vol. 100, nr 13, s. 1127-1127Artikkel i tidsskrift (Annet vitenskapelig)
  • 56.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Tonsillit (faryngo-tonsillit) hos barn [pharyngotonsillitis in children].2002Annet (Annet vitenskapelig)
  • 57.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Treatment of impetigo - Save mupirocin: Letter2004Inngår i: BMJ. British Medical Journal, E-ISSN 1756-1833, Vol. 329, nr 7472, s. 979-979Artikkel i tidsskrift (Annet vitenskapelig)
  • 58.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Vaccinationer, barn2004Annet (Annet vitenskapelig)
  • 59.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    ”Visst finns det belägg för att vinst i vården ger sämre kvalitet”2012Inngår i: Dagens Nyheter, ISSN 1101-2447, nr 20120725, s. Debatt-Artikkel i tidsskrift (Annet (populærvitenskap, debatt, mm))
  • 60.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Bergström, Sten-Erik
    Karolinska institutet.
    Hermansson, Ann
    Lunds universitet.
    Tessin, Ingemar
    Göteborgs universitet.
    Hellberg, Christel
    SBU.
    Mowafi, Frida
    SBU.
    Granath, Anna A
    SBU.
    Behandling av luftvägsinfektioner hos barn med läkemedel och andra preparat2016Rapport (Fagfellevurdert)
  • 61.
    Axelsson, Inge
    et al.
    Lunds universitet.
    Bjelle, Anders
    Proteoglycan structure of bovine articular cartilage: variation with age and in osteoarthrosis1979Inngår i: Scandinavian Journal of Rheumatology, ISSN 0300-9742, Vol. 8, nr 4, s. 217-221Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Proteoglycan subunits (PGS) were isolated from bovine articular cartilage of calves and from cows, 18 months and 8 years old respectively. From the latter cartilage of osteoarthrotic and of non-osteoarthrotic sites was taken. PGS were characterized by gel-chromatography on Sepharose 2B columns and subjected to digestion with chondroitinase ABC and with papain. The isolated keratan sulphate-protein cores obtained from chondroitinase digestion were characterized on Sepharose 4B and the chondroitin sulphate chains on Sephadex G-200 gels. A larger molecular size of PGS was found in calf cartilage than in the other samples. This was attributed to the larger molecular size of chondroitin, whereas no change was observed in the keratan sulphate-protein cores. No change was observed in molecular size of PGS, isolated chondroitin sulphates or keratan sulphate-protein cores in osteoarthrosis in compariith non-osteoarthrotic cartilage from the same joint or from younger adult animals.

  • 62.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Björnson, Stefan
    Ingelstam, Lars
    Jonter, Thomas
    Larsson, Jan
    Rydén, Lars
    Södersten, Elisabet
    Tondel, Martin
    Så kan Sverige verka för en värld utan kärnvapen2013Inngår i: Aftonbladet, ISSN 1103-9000Artikkel, omtale (Annet (populærvitenskap, debatt, mm))
  • 63.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Hasselström, J
    Feber hos barn - ibuprofen eller paracetamol [fever in children – ibuprofen or paracetamol (acetaminophen)]. 1177 Vårdguiden, Rådgivningsstödet.2013Annet (Fagfellevurdert)
  • 64.
    Axelsson, Inge
    et al.
    Lunds universitet.
    Heinegard, D
    Characterization of keratan sulphate proteoglycans from bovine corneal stroma1978Inngår i: Biochemical Journal, ISSN 0264-6021, Vol. 169, nr 3, s. 517-530Artikkel i tidsskrift (Fagfellevurdert)
  • 65.
    Axelsson, Inge
    et al.
    Lunds universitet.
    Heinegård, D.
    Characterization of chondroitin sulfate-rich proteoglycans from bovine corneal stroma.1980Inngår i: Experimental Eye Research, ISSN 0014-4835, Vol. 31, s. 57-66Artikkel i tidsskrift (Fagfellevurdert)
  • 66.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Hellman, J
    Behandlingsrekommendationer för vanliga infektioner i öppenvård [National guidelines for treatment of common infections in ambulatory care]2013Rapport (Fagfellevurdert)
  • 67.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Högberg, Cecilia
    Kjellberg, Mattias
    (Pseudo)krupp, luftanfuktning och steroidval2001Inngår i: Läkartidningen, ISSN 0023-7205, Vol. 98, nr 12, s. 1432-1432Artikkel i tidsskrift (Annet vitenskapelig)
  • 68.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Lind, Josefine
    Svenska läkare mot kärnvapen.
    Kriminalisera kärnvapen2017Inngår i: Hållbarhetens många ansikten: samtal, forskning och fantasier / [ed] Edith Andresen, Gustav Lidén, Sara Nyhlén, Sundsvall: Mid Sweden University , 2017, s. 102-107Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 69.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Malmvall, BE
    Mölstad, S
    Luftvägsinfektioner hos barn och vuxna: [respiratory infections in children and adults]2011Inngår i: Läkemedelsboken 2011/2012, Uppsala: Läkemedelsverket , 2011, s. 713-741Kapittel i bok, del av antologi (Fagfellevurdert)
  • 70.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Malmvall, Bo-Erik
    Mölstad, Sigvard
    Luftvägsinfektioner hos barn och vuxna2009Inngår i: Läkemedelsboken 2009-2010, Stockholm: Apoteket AB , 2009, s. 670-695Kapittel i bok, del av antologi (Annet vitenskapelig)
    Abstract [sv]

    Luftvägsinfektioner är en av de vanligaste

    orsakerna till ett akut besök i sjukvården.

    Antalet läkarbesök och antibiotikarecept

    ökar markant några veckor efter daghemseller

    skolstarten och minskar under lovperioder.

    Hos läkare och allmänhet finns en

    ökad medvetenhet om nödvändigheten av

    att vara försiktig med antibiotika. Flera

    studier har visat att nyttan av antibiotika

    är liten vid flera av våra vanligaste bakteriella

    infektioner, vilket också framkommit

    i de nya nationella rekommendationerna

    för handläggning av öroninflammationer

    (år 2000), halsinfektioner (år 2001), bihåleinfektioner

    (år 2005) och nedre luftvägsinfektioner

    (år 2008) (,

    ).

    En hög följsamhet till barnvaccinationsprogrammet

    och en hög vaccinationsgrad

    av äldre mot influensa och pneumokocker

    förebygger infektioner och bakteriella komplikationer

    och medför minskad morbiditet

    och mortalitet. Förbättrad basal hygien,

    speciellt i småbarnsgrupper, med handtvätt,

    pappersnäsdukar och pappershanddukar

    kan minska infektionsspridning och sjuklighet

    i luftvägsinfektioner.

     

  • 71.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Marnetoft, Sven Uno
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Benefits and harms of sick leave: A systematic review of randomised controlled trials2010Inngår i: International Journal of Rehabilitation Research, ISSN 0342-5282, E-ISSN 1473-5660, Vol. 33, nr 1, s. 1-3Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    The aim of this study was to try to identify those randomized controlled trials that compare sick leave with no sick leave or a different duration or degree of sick leave. A comprehensive, systematic, electronic search of Clinical Evidence, the Cochrane Library and PubMed, and a manual search of the Campbell Library and a journal supplement was carried out. Only two studies with randomization of sick leave were found. Patients, who were suspected of having whiplash injuries following a car accident, were randomly assigned to either 14 days on sick leave wearing a neck collar, or no neck collar or sick leave, and employees with musculoskeletal disorders were randomized to part-time sick leave and work adjustments, or full-time sick leave. Over 99% of the studies on sick leave were observational. The reason for the scarcity of randomized controlled trials is unknown. There is a definite, urgent need for randomized, controlled studies of the effects that sick leave has on health issues.

     

     

  • 72.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Mölstad, S
    Mindre antibiotika ska ges vid öroninflammation. Aktiv exspektans gäller för 1–12-åringar – tonåringar och vuxna får antibiotika: [Less antibiotics should be used for acute otitis media]. Medicinsk kommentar [commissioned editorial].2011Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 108, nr 19, s. 1044-1045Artikkel i tidsskrift (Annet vitenskapelig)
  • 73.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Nasta, F.
    Båda barn- och ungdomskliniken, Östersunds sjukhus, Sweden.
    Nygamla mediciner mot krupp och krampanfall hos barn: Oralt dexametason och buckalt midazolam kan ge bättre behandling2014Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 110, nr 48, s. 2163-Artikkel i tidsskrift (Annet vitenskapelig)
  • 74.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för omvårdnad. Östersund Hosp, Östersund.
    Naumburg, Estelle
    Umeå Univ, Umeå.
    Prietsch, Silvio O. M.
    Fed Univ Rio Grande, Rio Grande, RS, Brazil.
    Zhang, Linjie
    Fed Univ Rio Grande, Rio Grande, RS, Brazil.
    Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth (review)2019Inngår i: Cochrane Database of Systematic Reviews, ISSN 1469-493X, E-ISSN 1469-493X, nr 6, artikkel-id CD010126Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Background Inhaled corticosteroids (ICS) are the most effective treatment for children with persistent asthma. Although treatment with ICS is generally considered to be safe in children, the potential adverse effects of these drugs on growth remains a matter of concern for parents and physicians. Objectives To assess the impact of different inhaled corticosteroid drugs and delivery devices on the linear growth of children with persistent asthma. Search methods We searched the Cochrane Airways Trials Register, which is derived from systematic searches of bibliographic databases including CENTRAL, MEDLINE, Embase, CINAHL, AMED and PsycINFO. We handsearched respiratory journals and meeting abstracts. We also conducted a search of ClinicalTrials. gov and manufacturers' clinical trial databases, or contacted the manufacturer, to search for potential relevant unpublished studies. The literature search was initially conducted in September 2014, and updated in November 2015, September 2018, and April 2019. Selection criteria We selected parallel-group randomized controlled trials of at least three months' duration. To be included, trials had to compare linear growth between different inhaled corticosteroid molecules at equivalent doses, delivered by the same type of device, or between different devices used to deliver the same inhaled corticosteroid molecule at the same dose, in children up to 18 years of age with persistent asthma. Data collection and analysis At least two review authors independently selected studies and assessed risk of bias in included studies. The data were extracted by one author and checked by another. The primary outcome was linear growth velocity. We conducted meta-analyses using Review Manager 5.3 software. We used mean differences (MDs) and 95% confidence intervals (CIs) as the metrics for treatment effects, and the random-effects model for meta-analyses. We did not perform planned subgroup analyses due to there being too few included trials. Main results We included six randomized trials involving 1199 children aged from 4 to 12 years (per-protocol population: 1008), with mild-to-moderate persistent asthma. Two trials were from single hospitals, and the remaining four trials were multicentre studies. The duration of trials varied from six to 20 months. One trial with 23 participants compared fluticasone with beclomethasone, and showed that fluticasone given at an equivalent dose was associated with a significant greater linear growth velocity (MD 0.81 cm/year, 95% CI 0.46 to 1.16, low certainty evidence). Three trials compared fluticasone with budesonide. Fluticasone given at an equivalent dose had a less suppressive effect than budesonide on growth, as measured by change in height over a period from 20 weeks to 12 months (MD 0.97 cm, 95% CI 0.62 to 1.32; 2 trials, 359 participants; moderate certainty evidence). However, we observed no significant difference in linear growth velocity between fluticasone and budesonide at equivalent doses (MD 0.39 cm/year, 95% CI -0.94 to 1.73; 2 trials, 236 participants; very low certainty evidence). Two trials compared inhalation devices. One trial with 212 participants revealed a comparable linear growth velocity between beclomethasone administered via hydrofluoroalkane-metered dose inhaler (HFA-MDI) and beclomethasone administered via chlorofluorocarbon- metered dose inhaler (CFC-MDI) at an equivalent dose (MD-0.44 cm/year, 95% CI -1.00 to 0.12; low certainty evidence). Another trial with 229 participants showed a small but statistically significant greater increase in height over a period of six months in favour of budesonide via Easyhaler, compared to budesonide given at the same dose via Turbuhaler (MD 0.37 cm, 95% CI 0.12 to 0.62; low certainty evidence). Authors' conclusions This review suggests that the drug molecule and delivery device may impact the effect size of ICS on growth in children with persistent asthma. Fluticasone at an equivalent dose seems to inhibit growth less than beclomethasone and budesonide. Easyhaler is likely to have less adverse effect on growth than Turbuhaler when used for delivery of budesonide. However, the evidence from this systematic review of head-to-head trials is not certain enough to inform the selection of inhaled corticosteroid or inhalation device for the treatment of children with persistent asthma. Further studies are needed, and pragmatic trials and real-life observational studies seem more attractive and feasible.

  • 75.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för omvårdnad. Östersunds sjukhus.
    Naumburg, Estelle
    Umeå universitet.
    Prietsch, Sílvio O. M.
    Federal University of Rio Grande, Rio Grande, Brazil.
    Zhang, Linjie
    Federal University of Rio Grande, Rio Grande, Brazil.
    Effects of inhaled corticosteroids on growth in children with persistent asthma: Impact of drug molecules and delivery devices – An overview of Cochrane reviews2019Inngår i: Paediatric Respiratory Reviews, ISSN 1526-0542, E-ISSN 1526-0550, Vol. 32, s. 28-29Artikkel i tidsskrift (Fagfellevurdert)
  • 76.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Prietsch, SOM
    Rio Grande University.
    Zhang, L
    Rio Grande University.
    Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth (Protocol)2012Inngår i: Cochrane Database of Systematic Reviews, ISSN 1469-493X, E-ISSN 1469-493X, nr 10, s. 1-8Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    This is the protocol for a review and there is no abstract. The objectives are as follows:

    To assess the effects of different inhaled corticosteroids (ICS) and different delivery devices on the linear growth of children with persistent asthma.

  • 77.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Rosen, I A
    Impetigo2003Annet (Annet vitenskapelig)
    Abstract [en]

    Clinical practice guidelines for impetigo

  • 78.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Silfverdal, Sven Arne
    Infektionssjukdomar2011Inngår i: Pediatrik:  [Pediatrics. Textbook for medical students].   / [ed] Gustafsson J, Moell C., Stockholm: Liber, 2011, 1Kapittel i bok, del av antologi (Annet vitenskapelig)
  • 79.
    Axelsson, Inge
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Silfverdal, Sven Arne
    Umea Univ, Dept Clin Sci, Umea, Sweden.
    Pneumonia mortality among children in Brazil - a success story [Mortalidade por pneumonia entre crianças brasileiras: Uma história de sucesso]: Editorial2011Inngår i: Jornal de Pediatria, ISSN 0021-7557, E-ISSN 1678-4782, Vol. 87, nr 2, s. 85-87Artikkel i tidsskrift (Annet vitenskapelig)
  • 80. Dahl, IMS
    et al.
    Axelsson, Inge
    Lunds universitet.
    The inhibition by retinoic acid of the biosynthesis of proteoglycans in corneal cell cultures1980Inngår i: Experimental Eye Research, ISSN 0014-4835, Vol. 31, nr 4, s. 443-450Artikkel i tidsskrift (Fagfellevurdert)
  • 81.
    Edler, Gertrud
    et al.
    Umeå universitet.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad. Östersund Hospital.
    Barker, Gillian M
    Uppsala universitet.
    Lie, Susanne
    Statens helsetilsyn, Oslo.
    Naumburg, Estelle
    Umeå university.
    Serious complications in male infant circumcisions in Scandinavia indicate that this always be performed as a hospital-based procedure2016Inngår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 105, nr 7, s. 842-850Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aim:More than 7000 male circumcisions are performed in Scandinavia every year. Circumcision is regulated in different ways in Sweden and Denmark and Norway. This study reviewed and described factors associated with complications of circumcision in infant boys in Scandinavia over the last two decades and discussed how these complications could be avoided. Methods: Data on significant complications following circumcision on boys under the age of one in Scandinavia over the last 20 years were collected. Information was retrieved from testimonies of circumcisers, witnesses, medical records and verdicts. A systematic review was performed of fatal cases in the literature. Results: We found that 32 cases had been reported to the health authorities in the three countries, and we identified a total of 74 complications in these cases. These included four boys with severe bleeding and circulatory shock, which ended in the death of one boy.Other less serious complications may have occurred in other boys, but not been reported. Conclusion: Complications following male circumcision in Scandinavia were relatively rare,but serious complications did occur. Based on the analyses of the severe cases, we argue that circumcision should only be performed at hospitals with 24-hour emergency departments.

  • 82.
    Edler, Gertrud
    et al.
    Umeå universitet.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Barker, Gillian M
    Uppsala universitet.
    Lie, Susanne
    Statens helsetilsyn, Oslo.
    Naumburg, Estelle
    Umeå university.
    Säkerheten vid omskärelse av pojkar måste bli bättre2016Inngår i: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 113, artikkel-id D4CCArtikkel i tidsskrift (Annet vitenskapelig)
  • 83. Eriksson, BKG
    et al.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Rydström, H
    Jörbäck, H
    Grupp A streptokocker (GAS) [group A streptococci]2004Inngår i: INFPREG (databas), , s. -Annet (Annet vitenskapelig)
  • 84. Flinck, A
    et al.
    Paludan, A
    Matsson, L
    Holm, AK
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Oral findings in a group of newborn Swedish children.1994Inngår i: International Journal of Paediatric Dentistry, ISSN 0960-7439, Vol. 4, nr 2, s. 67-73Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Oral examinations were performed of 1021 newborn Swedish children, of whom 101 were re-examined after 2-3 or 4-5 months. The most common findings, registered in 74.9% of the children, were of oral mucosal cysts situated either palatally or on the alveolar ridges. The majority of the palatal cysts disappeared shortly after birth, and some alveolar cysts appeared after birth. Ankyloglossia was found in 2.5% of the children, and Fordyce spots in 1.0%. No natal teeth were found. The upper labial frenum was attached to the crest of the alveolar ridge in 76.7% of the children, palatally in 16.7% and buccally in 6.7%. The relationship of the alveolar ridges was recorded: the anterior segment of the mandibular ridge was distal to the maxillary in 99% of cases, and, posteriorly, the mandibular ridges were lingual to the maxillary in 97.6%. An open bite was found in 39.8% of the children.

  • 85. Heinegård, D
    et al.
    Axelsson, Inge
    Lunds universitet.
    Distribution of keratan sulfate in cartilage proteoglycans1977Inngår i: Journal of Biological Chemistry, ISSN 0021-9258, Vol. 252, nr 6, s. 1971-1979Artikkel i tidsskrift (Fagfellevurdert)
  • 86. Heinegård, D
    et al.
    Axelsson, Inge
    Inerot, S
    Skeletal keratan sulfate peptides from different tissues: Characterization and alkaline degradation.1979Inngår i: Biochimica et Biophysica Acta, ISSN 0006-3002, Vol. 581, nr 1, s. 122-127Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Keratan sulfate-rich peptides were isolated after digestion of proteoglycans from bovine nasal cartilage and bovine nucleus pulposus with chondroitinase ABC, trypsin and chymotrypsin. The keratan sulfate enriched peptides from nucleus pulposus were larger than those from nasal cartilage. Keratan sulfate chains were isolated after treatment of the keratan sulfate-rich peptides under alkaline, reductive conditions. Proteoglycans from nucleus pulposus contain longer keratan sulfate chains, as is shown primarily by gel chromatography of the keratan sulfate-rich peptides and the keratan sulfate chains, but also from end-group analyses of the keratan sulfate chains.

  • 87.
    Irevall, Tommie
    et al.
    regionjh.
    Axelsson, Inge
    Östersund Hospital.
    Naumburg, Estelle
    Regionjh.
    B12 deficiency is common in infants and is accompanied by serious neurological symptons2017Inngår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, nr 1, s. 101-104Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aim

    Adverse neurological symptoms have been linked to vitamin B12 deficiency in infants. This explorative study described the clinical presentation associated with vitamin B12 deficiency in this age group.

    Methods

    The study comprised infants who were born between 2004 and 2012 and were tested for vitamin B12 levels after they were admitted to a hospital with neurological symptoms at less than one year of age. Vitamin B12 deficiency was defined as low cobalamin in serum and/or increased homocysteine and/or increased methylmalonate. It was diagnosed according to the applicable International Classification of Diseases, 10th revision, and recorded as vitamin B12 deficiency in the medical records. All information was retrieved from medical records and compared to symptomatic infants with normal levels.

    Results

    Of the 121 infants tested, 35 had vitamin B12 deficiency and 86 had normal levels. Vitamin B12 deficiency was diagnosed at an average age of 1.7 months and was more common among boys. Seizures and apparent life-threatening events were the most common symptoms among infants with B12 deficiency compared to infants with normal levels.

    Conclusion

    Vitamin B12 deficiency was more common in infants than we expected and presented with severe symptoms, such as seizures and apparent life-threatening events.

  • 88.
    Melin-Johansson, Christina
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad. Östersund Hosp, Östersund, Sweden.
    Jonsson Grundberg, Marie
    Östersund Hosp, Östersund, Sweden.
    Hallqvist, Frida
    Östersund Hosp, Östersund, Sweden.
    When a child dies - parents’ experiences of palliative care: An integrative literature review2014Inngår i: Journal of Pediatric Nursing: Nursing Care of Children and Families, ISSN 0882-5963, E-ISSN 1532-8449, Vol. 29, nr 6, s. 660-669Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of this integrative review was to increase knowledge about parents' experiences of palliative care when their child is dying or has died due to illness using Whittemore and Knafl (2005) analysis process. Computerized databases were used to search the literature. Nine papers met the inclusion criteria. The analysis resulted in five categories: genuine communication, sincere relationships, respect as an expert, and alleviation of suffering and need of support, including 15 subcategories. Health professionals need education to provide high-quality pediatric palliative care. They especially need training concerning existential issues, and further studies need to be performed.

  • 89.
    Melin-Johansson, Christina
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Day, Annika
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Forslund, Ingela
    Supportive interventions and their impact on pediatric health care professionals’ emotional well-being: A systematic literature review2014Inngår i: Clinical Nursing Studies, ISSN 2324-7940, E-ISSN 2324-7959, Vol. 2, nr 4, s. 60-73Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The aim of this systematic literature review was to describe interventions supporting pediatric health care professionals to manage emotional strain when caring for children at the end-of-life. The review included five quantitative studies. Two categories were identified within the results: 1) Supportive interventions with the subcategories of educational interventions, peer support for grief, intensive training course, peer supported storytelling, and debriefing sessions; and 2) Effects of interventions, with the subcategories of increased understanding, increased confidence, creating meaning, grief management, and sense of well-being. Interventions that combine education and dialogue seem supportive, but debriefing might have the most impact on health care professionals’ emotional well-being. Future research should focus on deepening the understanding of the meaning of education and dialogue for health care professionals, further investigate the effects of debriefing, and focus on educational training around existential issues.

  • 90.
    Naumburg, Estelle
    et al.
    Department of Clinical Science, Paediatrics, Umeå University, Umeå, Sweden .
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Huber, Daniel
    Ostersund Hosp, Unit Res Educ & Dev, SE-83183 Ostersund, Sweden..
    Soderstrom, Lars
    Ostersund Hosp, Unit Res Educ & Dev, SE-83183 Ostersund, Sweden..
    Some neonatal risk factors for adult pulmonary arterial hypertension remain unknown2015Inngår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, nr 11, s. 1104-1108Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Aim: Pulmonary hypertension has been linked to premature birth, chronic lung disease, bronchopulmonary dysplasia and congenital heart disease. This national population-based registry study assessed the risk of adult pulmonary hypertension following premature birth, adjusted for known risk factors.

    Methods: We focused on adults in the Swedish Pulmonary Arterial Hypertension Registry, who were born prematurely, and controls randomly selected from the Swedish medical birth register and matched to each case by birth year and delivery hospital. Information on perinatal factors was also retrieved from the medical birth register. Conditional multiple logistic regression was used to evaluate the association between premature birth and adult pulmonary hypertension, taking into account the potential confounding factors.

    Results: The study population comprised 427 adults born between 1973 and 1996, with 61 cases and 366 controls. Adult pulmonary hypertension was associated with premature birth, with an odds ratio of 3.08 and 95% confidence interval of 1.21-7.87. The association did not alter after adjusting for potential confounders.

    Conclusion: By adjusting for factors linked to adult pulmonary hypertension, namely congenital heart defects, pulmonary diseases and premature birth, we were able to show that other unknown factors may influence the risk for pulmonary hypertension among adults who were born premature.

  • 91.
    Naumburg, Estelle
    et al.
    Regionjh.
    Söderström, Lars
    regionjh.
    Huber, D
    regionjh.
    Axelsson, Inge
    regionjh.
    Risk factors for pulmonary arterial hypertension in children and young adults2017Inngår i: Pediatric Pulmonology, ISSN 8755-6863, E-ISSN 1099-0496, Vol. 52, nr 5, s. 636-641Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objectives

    Pulmonary hypertension (PH) has been linked to preterm birth explained by congenital heart defects and pulmonary diseases.

    Working hypothesis

    Other factors may influence the risk of PH among adolescences and children born premature.

    Study design

    This national registry-based study assess risk of PH following premature birth adjusted for known risk factors.

    Patient-subject selection and methodology

    All cases born 1993–2010, identified by diagnostic codes applicable to PH and retrieved from the Swedish Registry of Congenital Heart Disease (N = 67). Six controls were randomly selected and matched to each case by year of birth and hospital by the Swedish Medical Birth Register (N = 402). Maternal and infant data related to preterm birth, pulmonary diseases, and congenital defects were retrieved. The association between preterm birth and pulmonary hypertension was calculated by conditional logistic regression taking into account potential confounding factors.

    Results

    One third of the cases and seven percent of the controls were born preterm in our study. Preterm birth was associated with PH, OR = 8.46 (95%CI 2.97–24.10) (P < 0.0001) even after adjusting for confounding factors. Other factors, such as acute pulmonary diseases, congenital heart defects, congenital diaphragm herniation, and chromosomal disorders were also associated with PH in the multivariate analysis.

    Conclusions

    Children and young adults born preterm are known to have an increased risk of PH, previously explained by congenital heart defects and pulmonary diseases. By adjusting for such factors, our study indicates that new factors may play a role in the risk of developing PH among children born preterm. 

  • 92.
    Norman, C
    et al.
    Smittskyddsinstitutet.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Bakgrundsdokumentation till kunskapsunderlaget Tecken på allvarlig infektion hos barn2012Rapport (Fagfellevurdert)
  • 93.
    Norman, C
    et al.
    Smittskyddsinstitutet.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Tecken på allvarlig infektion hos barn: Ett kunskapsunderlag med förslag till handläggning i primärvård (preliminär version 2012-11-29)2012Rapport (Fagfellevurdert)
    Abstract [sv]

    Smittskyddsinstitutet anordnade i mars 2012 ett expertmöte om tecken på allvarlig infektion hos barn. I mötet deltog experter med kunskap och erfarenhet av handläggning av barn inom primärvård och slutenvård. Syftet med mötet var att presentera relevant bakgrundsdokumentation och utifrån denna sätta samman ett kunskapsunderlag med förslag för handläggning av barn med tecken på allvarlig infektion. Bakgrundsdokumentationen är framtagen av enskilda experter och presenteras i ett separat dokument "Bakgrundsdokumentation till förslag för handläggning av barn med tecken på allvarlig infektion". Bakgrundsdokumenten är författarens enskilda manuskript. Budskapet i dessa delas därför inte alltid av expertgruppen i sin helhet.

    Kunskapsunderlaget med dess förslag till handläggning togs fram av deltagarna vid expertmötet.

    Dokumentet "Feverish illness in children" (http://www.nice.org.uk/CG047) från det brittiska National Institute for Health and Clinical Excellence (NICE) är huvudkälla för detta kunskapsunderlag men det grundar sig också på många andra studier som finns listade i bakgrundsdokumenten till detta dokument där de också diskuteras.

  • 94. Russell, K
    et al.
    Robinson, J
    Yorke, D
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    The Cochrane Library and Treatment for Community Acquired Pneumonia in Children: An Overview of Reviews2009Inngår i: Evidence-Based Child Health, ISSN 1557-6272, Vol. 4, nr 3, s. 1149-1164Artikkel i tidsskrift (Fagfellevurdert)
  • 95. Smedsaas-Löfvenberg, A
    et al.
    Nilsson, K
    Moa, G
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Nebulization of drugs in a nasal CPAP system.1999Inngår i: Acta Paediatrica, ISSN 0803-5253, Vol. 88, nr 1, s. 89-92Artikkel i tidsskrift (Fagfellevurdert)
  • 96. Stålsby Lundborg, Cecilia
    et al.
    Olsson, Eva
    Mölstad, Sigvard
    André, Malin
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Erikssojn, Margareta
    Hoffman, Mikael
    Odenholt, Inga
    Runehagen, Arne
    Schwan, Åke
    Wahlström, Rolf
    Antibiotic prescribing in outpatients: a 1-week diagnosis & prescribing study in 5 counties in Sweden2002Inngår i: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 34, nr 6, s. 442-448Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A diagnosis-antibiotic prescribing study initiated by the Swedish Strategic Programme for the Rational Use of Antimicrobial Agents and Surveillance of Resistance was performed in 5 counties in Sweden (total 1,290,000 inhabitants) during 1 week in November 2000. The aims of the study were to analyse diagnoses and antibiotics prescribed for outpatients and to appraise the feasibility of the data collection method. Physicians in primary care and departments of ENT, paediatrics and infectious diseases completed a questionnaire for each patient with an infectious disease complaint, including information about age, sex, diagnosis, diagnostic methods used and treatment. When an antibiotic was prescribed, the type and duration of treatment were noted. A total of 7,071 forms were returned, of which 7,029 included information on diagnosis; infections of the respiratory tract, urinary tract and the skin or soft tissues were responsible for 70%, 14% and 10% of the visits, respectively. Antibiotics were prescribed in 59% of all cases and phenoxymethylpenicillin was the most commonly prescribed antibiotic. Of the forms returned, 94% emanated from primary care centres. In conclusion, this study provides information on the treatment pattern associated with various diagnoses and the pattern of use of various antibiotics. Such a study is relatively simple to perform and entails only a small extra workload for the participants.

  • 97.
    Svedlund, Marianne
    et al.
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Acute myocardial infarction in middle-aged women: narrations from the patients and their partners during rehabilitation2000Inngår i: Intensive and Critical Care Nursing, ISSN 0964-3397, Vol. 16, nr 4, s. 256-265Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The purpose of this study was to examine the meaning of lived experiences after an acute myocardial infarction (AMI) and being a partner to an afflicted woman, as it is narrated during rehabilitation. Nine women and their partners narrated their experiences three and twelve months after AMI. The interview texts were transcribed and then interpreted, using a phenomenological-hermeneutic method inspired by the philosophy of Ricoeur. The result showed that their experiences of the illness contained two themes: 'rehabilitation needed' and 'loss of freedom' which contains eight sub-themes; 'adapting to it', 'struggling against it', 'living as normally as possible', 'having insight into how it can be', 'feeling guilty and ashamed about being weak', 'withholding feelings', 'feeling useless', and 'feeling fatigued and losing strength'. After further interpretation, the themes gave a deeper meaning of living with AMI and how it affects women and their partners. The women conceded that they felt distressed and vulnerable but struggled against the fear the illness means. The partner's role appears to be one of trying to adapt to the women's experiences of the illness. That the women withheld their feelings and did not talk about them indicates a lack of communication between the couples. As coronary care nurses often come very close both to the afflicted persons and the relatives they fill an important function in each patient's recovery. The nurses could help and prepare the patients and their relatives to understand better such feelings and reactions as could appear after discharge from hospital.

  • 98.
    Zhang, L
    et al.
    Federal University of Rio Grande, Faculty of Medicine, Rio Grande, RS, Brazil.
    Prietsch, SOM
    Federal University of Rio Grande, Faculty of Medicine, Rio Grande, RS, Brazil.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Halperin, SA
    Halifax Dalhousie University, IWK Health Centre, Canadian Center for Vaccinology, Halifax, Nova Scotia, Canada.
    Acellular vaccines for preventing whooping cough in children2012Inngår i: Cochrane Database of Systematic Reviews, ISSN 1469-493X, E-ISSN 1469-493X, nr 3, artikkel-id CD001478Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    A B S T R A C T

    Background

    Routine use of whole-cell pertussis (wP) vaccines was suspended in some countries in the 1970s and 1980s because of concerns about adverse effects. Following such action, there was a resurgence of whooping cough. Acellular pertussis (aP) vaccines, containing purified or recombinant Bordetella pertussis (B. pertussis) antigens, were developed in the hope that they would be as effective, but less reactogenic than the whole-cell vaccines.

    Objectives

    To assess the efficacy and safety of acellular pertussis vaccines in children.

    Search methods

    We searched theCochrane Register ofControlledTrials (CENTRAL) (TheCochrane Library 2011, Issue 4)which contains theCochrane Acute Respiratory Infections Group’s Specialised Register, MEDLINE (1950 to December week 4, 2011), EMBASE (1974 to January 2012), Biosis Previews (2009 to January 2012), and CINAHL (2009 to January 2012).

    Selection criteria

    We selected double-blind randomised efficacy and safety trials of aP vaccines in children up to six years old, with active follow-up of participants and laboratory verification of pertussis cases.

    Data collection and analysis

    Two review authors independently extracted data and assessed the risk of bias in the studies. Differences in trial design precluded a meta-analysis of the efficacy data. We pooled the safety data from individual trials using a random-effects meta-analysis model.

    Main results

    We included six efficacy trials with a total of 46,283 participants and 52 safety trials with a total of 136,541 participants. Most of the safety trials did not report the methods for random sequence generation, allocation concealment and blinding, which made it difficult to assess the risk of bias in the studies. The efficacy of multi-component (three) vaccines varied from 84% to 85% in preventing typical whooping cough (characterised by 21 or more consecutive days of paroxysmal cough with confirmation of B. pertussis infection by culture, appropriate serology or contact with a household member who has culture-confirmed pertussis), and from 71% to 78% in Acellular vaccines for preventing whooping cough in children (Review) preventing mild pertussis disease (characterised by seven or more consecutive days of cough with confirmation of B. pertussis infection by culture or appropriate serology). In contrast, the efficacy of one- and two-component vaccines varied from 59% to 75% against typical whooping cough and from 13% to 54% against mild pertussis disease. Multi-component acellular vaccines are more effective than low-efficacy whole-cell vaccines, but may be less effective than the highest-efficacy whole-cell vaccines. Most systemic and local adverse events were significantly less common with aP vaccines than with wP vaccines for the primary series as well as for the booster dose.

    Authors’ conclusions

    Multi-component (three) aP vaccines are effective and show less adverse effects than wP vaccines for the primary series as well as for booster doses.

    P L A I N L A N G U A G E S U M M A R Y

    Acellular vaccines for preventing whooping cough in children

    Whooping cough (pertussis) can be a serious respiratory infection. Vaccines made from killed whole Bordetella pertussis (B. pertussis) were developed but they could cause severe neurologic disorders such as convulsions, encephalopathy and hypotonic-hyporesponsive episodes, as well as minor adverse events, such as anorexia, drowsiness, fever, irritability and fretfulness, prolonged crying, vomiting, and injection site pain/redness/swelling/induration. This led to a fall in immunisation rates, which resulted in an increase in the incidence of whooping cough. Acellular pertussis (aP) vaccines (containing purified or recombinant B. pertussis antigens) were developed in the hope that they would be as effective but less reactogenic than the whole-cell pertussis (wP) vaccines.

    This updated review included six efficacy trials with a total of 46,283 participants and 52 safety trials with a total of 136,541 participants. The efficacy of multi-component (three) acellular vaccines varied from 84% to 85% in preventing typical whooping cough (characterised by 21 or more consecutive days of paroxysmal cough with confirmation of B. pertussis infection by culture, appropriate serology or contact with a household member who has culture-confirmed pertussis) and from 71% to 78% in preventing mild pertussis disease (characterised by seven or more consecutive days of cough with confirmation of B. pertussis infection by culture or appropriate serology). One- and two-component acellular vaccines were less effective. Most systemic and local adverse events were significantly less common with aP than with wP vaccines for the primary series as well as for the booster dose. This review found that multi-component vaccines which contain three or more aP components are effective, with less adverse effects than wP vaccines.

  • 99. Zhang, Linjie
    et al.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Institutionen för hälsovetenskap.
    Prietsch, Silvio
    Inhaled corticosteroids in children with persistent asthma: effects on growth [protocol].2011Inngår i: Cochrane Database of Systematic Reviews, ISSN 1469-493X, E-ISSN 1469-493X, nr DecemberArtikkel i tidsskrift (Fagfellevurdert)
  • 100.
    Zhang, Linjie
    et al.
    Federal University of Rio Grande, Faculty of Medicine, Rio Grande, RS, Brazil.
    Prietsch, Silvio O. M.
    Federal University of Rio Grande, Faculty of Medicine, Rio Grande, RS, Brazil.
    Axelsson, Inge
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för omvårdnad.
    Halperin, Scott A.
    Halifax Dalhousie University, IWK Health Centre, Canadian Center for Vaccinology, Halifax, NS, Canada.
    Acellular vaccines for preventing whooping cough in children2014Inngår i: Cochrane Database of Systematic Reviews, ISSN 1469-493X, E-ISSN 1469-493X, nr 9, artikkel-id CD001478Artikkel, forskningsoversikt (Fagfellevurdert)
    Abstract [en]

    Background Routine use of whole-cell pertussis (wP) vaccines was suspended in some countries in the 1970s and 1980s because of concerns about adverse effects. Following this action, there was a resurgence of whooping cough. Acellular pertussis (aP) vaccines, containing purified or recombinant Bordetella pertussis (B. pertussis) antigens, were developed in the hope that they would be as effective, but less reactogenic than the whole-cell vaccines. This is an update of a Cochrane review first published in 1999, and previously updated in 2012. In this update, we included no new studies. Objectives To assess the efficacy and safety of acellular pertussis vaccines in children and to compare them with the whole-cell vaccines. Search methods We searched CENTRAL (2013, Issue 12), MEDLINE (1950 to January week 2, 2014), EMBASE (1974 to January 2014), Biosis Previews (2009 to January 2014) and CINAHL (2009 to January 2014). Selection criteria We selected double-blind randomised efficacy and safety trials of aP vaccines in children up to six years old, with active follow-up of participants and laboratory verification of pertussis cases. Data collection and analysis Two review authors independently extracted data and assessed the risk of bias in the studies. Differences in trial design precluded a meta-analysis of the efficacy data. We pooled the safety data from individual trials using a random-effects meta-analysis model. Main results We included six efficacy trials with a total of 46,283 participants and 52 safety trials with a total of 136,541 participants. Most of the safety trials did not report the methods for random sequence generation, allocation concealment and blinding, which made it difficult to assess the risk of bias in the studies. The efficacy of multi-component (>= three) vaccines varied from 84% to 85% in preventing typical whooping cough (characterised by 21 or more consecutive days of paroxysmal cough with confirmation of B. pertussis infection by culture, appropriate serology or contact with a household member who has culture-confirmed pertussis), and from 71% to 78% in preventing mild pertussis disease (characterised by seven or more consecutive days of cough with confirmation of B. pertussis infection by culture or appropriate serology). In contrast, the efficacy of one-and two-component vaccines varied from 59% to 78% against typical whooping cough and from 41% to 58% against mild pertussis disease. Multi-component acellular vaccines are more effective than low-efficacy whole-cell vaccines, but may be less effective than the highest-efficacy whole-cell vaccines. Most systemic and local adverse events were significantly less common with aP vaccines than with wP vaccines for the primary series as well as for the booster dose. Authors' conclusions Multi-component (>= three) aP vaccines are effective in preventing whooping cough in children. Multi-component aP vaccines have higher efficacy than low-efficacy wP vaccines, but they may be less efficacious than the highest-efficacy wP vaccines. Acellular vaccines have fewer adverse effects than whole-cell vaccines for the primary series as well as for booster doses.

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