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  • 1. Middeldorp, Christel M.
    et al.
    Mahajan, Anubha
    Horikoshi, Momoko
    Robertson, Neil R.
    Beaumont, Robin N.
    Bradfield, Jonathan P.
    Bustamante, Mariona
    Cousminer, Diana L.
    Day, Felix R.
    De Silva, N. Maneka
    Guxens, Monica
    Mook-Kanamori, Dennis O.
    St Pourcain, Beate
    Warrington, Nicole M.
    Adair, Linda S.
    Ahlqvist, Emma
    Ahluwalia, Tarunveer S.
    Almgren, Peter
    Ang, Wei
    Atalay, Mustafa
    Auvinen, Juha
    Bartels, Meike
    Beckmann, Jacques S.
    Bilbao, Jose Ramon
    Bond, Tom
    Borja, Judith B.
    Cavadino, Alana
    Charoen, Pimphen
    Chen, Zhanghua
    Coin, Lachlan
    Cooper, Cyrus
    Curtin, John A.
    Custovic, Adnan
    Das, Shikta
    Davies, Gareth E.
    Dedoussis, George V.
    Duijts, Liesbeth
    Eastwood, Peter R.
    Eliasen, Anders U.
    Elliott, Paul
    Eriksson, Johan G.
    Estivill, Xavier
    Fadista, Joao
    Fedko, Iryna O.
    Frayling, Timothy M.
    Gaillard, Romy
    Gauderman, W. James
    Geller, Frank
    Gilliland, Frank
    Gilsanz, Vincente
    Granell, Raquel
    Grarup, Niels
    Groop, Leif
    Hadley, Dexter
    Hakonarson, Hakon
    Hansen, Torben
    Hartman, Catharina A.
    Hattersley, Andrew T.
    Hayes, M. Geoffrey
    Hebebrand, Johannes
    Heinrich, Joachim
    Helgeland, Oyvind
    Henders, Anjali K.
    Henderson, John
    Henriksen, Tine B.
    Hirschhorn, Joel N.
    Hivert, Marie-France
    Hocher, Berthold
    Holloway, John W.
    Holt, Patrick
    Hottenga, Jouke-Jan
    Hypponen, Elina
    Iniguez, Carmen
    Johansson, Stefan
    Jugessur, Astanand
    Kahonen, Mika
    Kalkwarf, Heidi J.
    Kaprio, Jaakko
    Karhunen, Ville
    Kemp, John P.
    Kerkhof, Marjan
    Koppelman, Gerard H.
    Korner, Antje
    Kotecha, Sailesh
    Kreiner-Moller, Eskil
    Kulohoma, Benard
    Kumar, Ashish
    Kutalik, Zoltan
    Lahti, Jari
    Lappe, Joan M.
    Larsson, Henrik
    Lehtimaki, Terho
    Lewin, Alexandra M.
    Li, Jin
    Lichtenstein, Paul
    Lindgren, Cecilia M.
    Lindi, Virpi
    Linneberg, Allan
    Liu, Xueping
    Liu, Jun
    Lowe, William L., Jr.
    Lundstrom, Sebastian
    Lyytikainen, Leo-Pekka
    Ma, Ronald C. W.
    Mace, Aurelien
    Magi, Reedik
    Magnus, Per
    Mamun, Abdullah A.
    Mannikko, Minna
    Martin, Nicholas G.
    Mbarek, Hamdi
    McCarthy, Nina S.
    Medland, Sarah E.
    Melbye, Mads
    Melen, Erik
    Mohlke, Karen L.
    Monnereau, Claire
    Morgen, Camilla S.
    Morris, Andrew P.
    Murray, Jeffrey C.
    Myhre, Ronny
    Najman, Jackob M.
    Nivard, Michel G.
    Nohr, Ellen A.
    Nolte, Ilja M.
    Ntalla, Ioanna
    O'Reilly, Paul
    Oberfield, Sharon E.
    Oken, Emily
    Oldehinkel, Albertine J.
    Pahkala, Katja
    Palviainen, Teemu
    Panoutsopoulou, Kalliope
    Pedersen, Oluf
    Pennell, Craig E.
    Pershagen, Goran
    Pitkanen, Niina
    Plomin, Robert
    Power, Christine
    Prasad, Rashmi B.
    Prokopenko, Inga
    Pulkkinen, Lea
    Raikkonen, Katri
    Raitakari, Olli T.
    Reynolds, Rebecca M.
    Richmond, Rebecca C.
    Rivadeneira, Fernando
    Rodriguez, Alina
    Mid Sweden University, Faculty of Human Sciences, Department of Psychology and Social Work. Univ Exeter, Med Sch, Inst Biomed & Clin Sci, Royal Devon & Exeter Hosp, Exeter EX2 5DW, Devon, England; Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London W2 1PG, England.
    Rose, Richard J.
    Salem, Rany
    Santa-Marina, Loreto
    Saw, Seang-Mei
    Schnurr, Theresia M.
    Scott, James G.
    Selzam, Saskia
    Shepherd, John A.
    Simpson, Angela
    Skotte, Line
    Sleiman, Patrick M. A.
    Snieder, Harold
    Sorensen, Thorkild I. A.
    Standl, Marie
    Steegers, Eric A. P.
    Strachan, David P.
    Straker, Leon
    Strandberg, Timo
    Taylor, Michelle
    Teo, Yik-Ying
    Thiering, Elisabeth
    Torrent, Maties
    Tyrrell, Jessica
    Uitterlinden, Andre G.
    van Beijsterveldt, Toos
    van der Most, Peter J.
    van Duijn, Cornelia M.
    Viikari, Jorma
    Vilor-Tejedor, Natalia
    Vogelezang, Suzanne
    Vonk, Judith M.
    Vrijkotte, Tanja G. M.
    Vuoksimaa, Eero
    Wang, Carol A.
    Watkins, William J.
    Wichmann, H-Erich
    Willemsen, Gonneke
    Williams, Gail M.
    Wilson, James F.
    Wray, Naomi R.
    Xu, Shujing
    Xu, Cheng-Jian
    Yaghootkar, Hanieh
    Yi, Lu
    Zafarmand, Mohammad Hadi
    Zeggini, Eleftheria
    Zemel, Babette S.
    Hinney, Anke
    Lakka, Timo A.
    Whitehouse, Andrew J. O.
    Sunyer, Jordi
    Widen, Elisabeth E.
    Feenstra, Bjarke
    Sebert, Sylvain
    Jacobsson, Bo
    Njolstad, Pal R.
    Stoltenberg, Camilla
    Smith, George Davey
    Lawlor, Debbie A.
    Paternoster, Lavinia
    Timpson, Nicholas J.
    Ong, Ken K.
    Bisgaard, Hans
    Bonnelykke, Klaus
    Jaddoe, Vincent W. V.
    Tiemeier, Henning
    Jarvelin, Marjo-Riitta
    Evans, David M.
    Perry, John R. B.
    Grant, Struan F. A.
    Boomsma, Dorret I.
    Freathy, Rachel M.
    McCarthy, Mark I.
    Felix, Janine F.
    Tiemeier, Hen-Ning
    The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects2019In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 34, no 3, p. 279-300Article in journal (Refereed)
    Abstract [en]

    The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.

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