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  • 1.
    Andersson, Eva
    et al.
    Sahlgrenska University Hospital.
    Knutsson, Anders
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Hagberg, S.
    Sahlgrenska University Hospital.
    Nilsson, T.
    Sundsvall Hospital.
    Karlsson, B.
    Umeå University.
    Alfredsson, L.
    Karolinska Institute.
    Torén, K.
    Sahlgrenska University Hospital.
    Incidence of asthma among workers exposed to sulfur dioxide and other irritant gases2006In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 27, no 4, p. 720-725Article in journal (Refereed)
    Abstract [en]

    The aim of the present study was to investigate whether repeated peak exposure (gassings) to sulphur dioxide (SO2) and other irritant gases increases the risk of new-onset asthma. A questionnaire was sent to 4,112 sulphite workers, of whom 1,919 completed the questionnaire and 396 completed the short-form questionnaire, which was sent out as a last reminder. A sample of 130 nonrespondents completed a telephone interview using the short-form questionnaire. The incidence of adult-onset, physician-diagnosed asthma during employment duration was analysed in relation to exposure to SO2 and gassings giving rise to respiratory symptoms. Incidence rates, as well as incidence rate ratios with 95% confidence interval (CI), were calculated. Further Cox regression models were used allowing assessment of hazard ratios (HR) stratified for sex and adjusted for atopy, smoking habits and age. The incidence rate for asthma among sulphite mill workers reporting gassings of SO2 was 6.2 out of 1,000 person-yrs, compared with 1.9 out of 1,000 person-yrs among subjects unexposed to SO2 and any gassings (HR (95% CI) 4.0 (2.1-7.7)). Among males reporting gassings to SO2, the HR (95% CI) for asthma was 5.8 (2.6-13) compared with unexposed males. In conclusion, repeated peak exposure to sulphur dioxide increased the incidence of asthma during work in sulphite pulp mills, which supports the hypothesis of irritant-induced asthma.

  • 2.
    Eriksson, Linda
    et al.
    Umeå universitet, Medicin.
    Schagatay, Filip
    Umeå universitet, Institutionen för folkhälsa och klinisk medicin.
    Sjöström, Rita
    Umeå universitet, Institutionen för samhällsmedicin och rehabilitering.
    Soderstrom, Lars
    Hanstock, Helen
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Sandström, Thomas
    Department of Medicine, Respiratory & allergy unit, Umeå university hospital, Umeå, Sweden.
    Stenfors, Nikolai
    Umeå universitet, Medicin.
    Symptoms of moderate exercise in subzero temperatures - An experimental exposure study2018In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 52Article in journal (Other academic)
    Abstract [en]

    Humans react to cold with various symptoms. Previous studies enquiring about symptoms during cold exposure have for the most part been population based studies using questionnaries and have focused on a narrow spectrum of symptoms. The purpose of this study was to study the effect of cold air and physical exercise on a wide range of symptoms in healthy individuals.

    A total of 31 healthy subjects were experimentally exposed to +10 °C and -10 °C in an environmental chamber for one hour, on two separate occasions. During each exposure, subjects performed an intermittent moderate-intensity running protocol between 62-78% of maximal oxygen consumption (VO2 max). At five timepoints, before, during and after the exposures, subjects were asked about 18 symptoms and their intensity. The Borg CR10 scale was used to rate the intensity from 0 to 11, where 0 meant "none" and 11 meant "maximal". The sum of all five Borg CR10-scores were added together to form a single score for each exposure. Paired Wilcoxon signed-rank test was used for analysis. Data are presented as medians.

    Symptoms of cough, eye irritation, physical discomfort, and cold extremities were present only at -10 °C. Compared to exercise in +10 °C, exercise in -10 °C induced significantly higher summed symptom scores for eye irritation 2.0 vs 0.5 (p=0.011), rhinitis 12.0 vs 8.0 (p=0.000), nasal irritation 3.5 vs 0.5 (p=0.001), cold face 7.0 vs 1.0 (p=0.000), physical discomfort 6.5 vs 0.0 (p=0.000), and cold extremities 10.0 vs 0.5 (p=0.000).

    In healthy subjects, moderate-intensity exercise in -10 °C can induce and enhance the intensity of a wide range of symptoms. Symptoms of the lower airways were infrequent and mild.

  • 3.
    Heikkila, Katriina
    et al.
    Finnish Inst Occupat Hlth, Helsinki, Finland.
    Madsen, Ida E. H.
    Natl Res Ctr Working Environm, Copenhagen, Denmark.
    Nyberg, Solja T.
    Finnish Inst Occupat Hlth, Helsinki, Finland.
    Fransson, Eleonor I.
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.
    Ahola, Kirsi
    Finnish Inst Occupat Hlth, Helsinki, Finland.
    Alfredsson, Lars
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.
    Bjorner, Jakob B.
    Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden.
    Borritz, Marianne
    Bispebjerg Hosp, Dept Occupat & Environm Med, Copenhagen, Denmark.
    Burr, Hermann
    Fed Inst Occupat Safety & Hlth BAuA, Berlin, Germany.
    Knutsson, Anders
    Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
    Koskenvuo, Markku
    Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
    Koskinen, Aki
    Finnish Inst Occupat Hlth, Helsinki, Finland.
    Nielsen, Martin L.
    Bispebjerg Hosp, Dept Occupat & Environm Med, Copenhagen, Denmark.
    Nordin, Maria
    Umea Univ, Dept Psychol, S-90187 Umea, Sweden.
    Pahkin, Krista
    Finnish Inst Occupat Hlth, Helsinki, Finland.
    Pentti, Jaana
    Finnish Inst Occupat Hlth, Turku, Finland.
    Rugulies, Reiner
    Natl Res Ctr Working Environm, Copenhagen, Denmark.
    Salo, Paula
    Finnish Inst Occupat Hlth, Turku, Finland.
    Shipley, Martin J.
    UCL, Dept Epidemiol & Publ Hlth, London, England.
    Suominen, Sakari B.
    Folkhalsan Res Ctr, Helsinki, Finland.
    Theorell, Tores
    Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.
    Vaananen, Ari
    Finnish Inst Occupat Hlth, Helsinki, Finland.
    Vahtera, Jussi
    Finnish Inst Occupat Hlth, Turku, Finland.
    Virtanen, Marianna
    Finnish Inst Occupat Hlth, Helsinki, Finland.
    Westerholm, Peter J. M.
    Uppsala Univ, Uppsala, Sweden.
    Batty, G. David
    UCL, Dept Epidemiol & Publ Hlth, London, England.
    Singh-Manoux, Archana
    UCL, Dept Epidemiol & Publ Hlth, London, England.
    Kivimaki, Mika
    UCL, Dept Epidemiol & Publ Hlth, London, England.
    Job strain and COPD exacerbations: an individual-participant meta-analysis2014In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 44, no 1, p. 247-251Article in journal (Refereed)
  • 4.
    Hilmarsen, CW
    et al.
    Norwegian Heart & Lung Patient Org, LHL Hlth Roros, Roros, Norway.
    Wilke, S
    Ctr Expertise Chron Organ Failure, Program Dev Ctr, CIRO, Horn, Netherlands.
    Engan, Harald
    Mid Sweden University, Faculty of Science, Technology and Media, Department of Ecotechnology and Sustainable Building Engineering. Norwegian Heart & Lung Patient Org, LHL Hlth Roros, Roros, Norway.
    Spruit, MA
    Ctr Expertise Chron Organ Failure, Program Dev Ctr, CIRO, Horn, Netherlands.
    Rodenburg, J
    Norwegian Heart & Lung Patient Org, LHL Hlth Roros, Roros, Norway.
    Janssen, DJ
    Ctr Expertise Chron Organ Failure, Program Dev Ctr, CIRO, Horn, Netherlands.
    Steinshamn, S
    Norwegian Heart & Lung Patient Org, LHL Hlth Roros, Roros, Norway.
    Jones, PW
    St Georges Univ London, Div Clin Sci, London, England.
    Wouters, EF
    Ctr Expertise Chron Organ Failure, Program Dev Ctr, CIRO, Horn, Netherlands.
    Oldervoll, L
    Norwegian Heart & Lung Patient Org, LHL Hlth Roros, Roros, Norway.
    Franssen, FM
    Ctr Expertise Chron Organ Failure, Program Dev Ctr, CIRO, Horn, Netherlands.
    Impact of symptoms of anxiety and depression on COPD Assessment Test (CAT) scores.2014In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 43, no 3, p. 898-900Article in journal (Other academic)
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