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  • 1.
    Carlberg, Michael
    et al.
    Örebro Univ, Örebro.
    Koppel, Tarmo
    Tallinn Univ Technol, Tallinn, Estonia.
    Ahonen, Mikko
    Mittuniversitetet, Fakulteten för naturvetenskap, teknik och medier, Avdelningen för informationssystem och -teknologi.
    Hardell, Lennart
    Örebro Univ, Örebro.
    Case-Control Study on Occupational Exposure to Extremely Low-Frequency Electromagnetic Fields and the Association with Meningioma2018Inngår i: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, artikkel-id 5912394Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Objective. Exposure to extremely low-frequency electromagnetic fields (ELF-EMF) was in 2002 classified as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer at WHO based on an increased risk for childhood leukemia. In case-control studies on brain tumors during 1997-2003 and 2007-2009 we assessed lifetime occupations in addition to exposure to different agents. The INTEROCC ELF-EMF Job-ExposureMatrix was used for associating occupations with ELF-EMF exposure (mu T) with meningioma. Cumulative exposure (mu T-years), average exposure (mu T), and maximum exposed job (mu T) were calculated. Results. No increased risk for meningioma was found in any category. For cumulative exposure in the highest exposure category 8.52+ mu T years odds ratio (OR) = 0.9, 95% confidence interval (CI) = 0.7-1.2, and.. linear trend = 0.45 were calculated. No statistically significant risks were found in different time windows. Conclusion. In conclusion occupational ELF-EMF was not associated with an increased risk for meningioma.

  • 2.
    Etehad Tavakol, Mahnaz
    et al.
    Isfahan University of Medical Sciences, Iran.
    Fatemi, Alimohammad
    Isfahan University of Medical Sciences, Iran.
    Karbalaie, Abdolamir
    KTH, Hälso- och systemvetenskap.
    Emrani, Zahra
    Isfahan University of Medical Sciences, Iran.
    Erlandsson, Björn-Erik
    KTH, Systemsäkerhet och organisation.
    Nailfold Capillaroscopy in Rheumatic Diseases: Which Parameters Should Be Evaluated?2015Inngår i: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, Vol. 2015, artikkel-id 974530Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Video nailfold capillaroscopy (NFC), considered as an extension of the widefield technique, allows a more accurate measuring andstoring of capillary data and a better defining, analyzing, and quantifying of capillary abnormalities. Capillaroscopic study is oftenperformed on the patients suspected of having microcirculation problems such as Raynaud’s phenomenon as the main indicationfor nailfold capillaroscopy. Capillaroscopic findings based on microcirculation studies can provide useful information in the fieldsof pathophysiology, differential diagnosis, and monitoring therapy. Nailfold capillaroscopy provides a vital assessment in clinicalpractices and research; for example, its reputation in the early diagnosis of systemic sclerosis is well established and it is also usedas a classification criterion in this regard. This review focuses on the manner of performing video nailfold capillaroscopy and on acommon approach for measuring capillary dimensions in fingers and toes.

  • 3.
    Fluck, Martin
    et al.
    Univ Zurich, Balgrist Univ Hosp, CH-8006 Zurich, Switzerland.
    Li, Ruowei
    Manchester Metropolitan Univ, Inst Biomed Res Human Movement & Hlth, Manchester M15 6BH, Lancs, England.
    Valdivieso, Paola
    Univ Zurich, Balgrist Univ Hosp, CH-8006 Zurich, Switzerland.
    Linnehan, Richard M.
    Johnson Space Ctr, Natl Aeronaut & Space Adm, Houston, TX USA.
    Castells, Josiane
    Univ St Etienne, Fac Med, EA4338, Lab Physiol Exercice, St Etienne, France.
    Tesch, Per
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för hälsovetenskap. Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
    Gustafsson, Thomas
    Karolinska Univ Hosp, Clin Physiol Karolinska Inst, Dept Lab Med, Stockholm, Sweden.
    Early Changes in Costameric and Mitochondrial Protein Expression with Unloading Are Muscle Specific2014Inngår i: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, artikkel-id 519310Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We hypothesised that load-sensitive expression of costameric proteins, which hold the sarcomere in place and position the mitochondria, contributes to the early adaptations of antigravity muscle to unloading and would depend on muscle fibre composition and chymotrypsin activity of the proteasome. Biopsies were obtained from vastus lateralis (VL) and soleus (SOL) muscles of eight men before and after 3 days of unilateral lower limb suspension (ULLS) and subjected to fibre typing and measures for costameric (FAK and FRNK), mitochondrial (NDUFA9, SDHA, UQCRC1, UCP3, and ATP5A1), and MHCI protein and RNA content. Mean cross-sectional area (MCSA) of types I and II muscle fibres in VL and type I fibres in SOL demonstrated a trend for a reduction after ULLS (0.05 <= P < 0.10). FAK phosphorylation at tyrosine 397 showed a 20% reduction in VL muscle (P = 0.029). SOL muscle demonstrated a specific reduction in UCP3 content (-23%; P = 0.012). Muscle-specific effects of ULLS were identified for linear relationships between measured proteins, chymotrypsin activity and fibre MCSA. The molecular modifications in costamere turnover and energy homoeostasis identify that aspects of atrophy and fibre transformation are detectable at the protein level in weight-bearing muscles within 3 days of unloading.

  • 4.
    Fransson, Eleonor I.
    et al.
    Jonkoping Univ, Sch Hlth Sci, S-55111 Jonkoping, Sweden.;Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden..
    Stadin, Magdalena
    Jonkoping Univ, Sch Hlth Sci, S-55111 Jonkoping, Sweden..
    Nordin, Maria
    Umea Univ, Dept Psychol, S-90187 Umea, Sweden.;Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden..
    Malm, Dan
    Jonkoping Univ, Sch Hlth Sci, S-55111 Jonkoping, Sweden.;Cty Hosp Ryhov, Dept Internal Med, S-55185 Jonkoping, Sweden..
    Knutsson, Anders
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för hälsovetenskap.
    Alfredsson, Lars
    Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden..
    Westerholm, Peter J. M.
    Uppsala Univ, Occupat & Environm Med, S-75185 Uppsala, Sweden..
    The Association between Job Strain and Atrial Fibrillation: Results from the Swedish WOLF Study2015Inngår i: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, artikkel-id 371905Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction. Atrial fibrillation (AF) is a common heart rhythmdisorder. Several life-style factors have been identified as risk factors for AF, but less is known about the impact of work-related stress. This study aims to evaluate the association between work-related stress, defined as job strain, and risk of AF. Methods. Data from the Swedish WOLF study was used, comprising 10,121 working men and women. Job strain was measured by the demand-control model. Information on incident AF was derived from national registers. Cox proportional hazard regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between job strain and AF risk. Results. In total, 253 incident AF cases were identified during a total follow-up time of 132,387 person-years. Job strain was associated with AF risk in a time-dependent manner, with stronger association after 10.7 years of follow-up (HR 1.93, 95% CI 1.10-3.36 after 10.7 years, versus HR 1.11, 95% CI 0.67-1.83 before 10.7 years). The results pointed towards a dose-response relationship when taking accumulated exposure to job strain over time into account. Conclusion. This study provides support to the hypothesis that work-related stress defined as job strain is linked to an increased risk of AF.

  • 5.
    Zubak, Zoran
    et al.
    Special Hosp Biograd, Biograd, Croatia; Univ Mostar, Mostar, Bosnia & Herceg..
    Terzic, Admir
    Univ Tuzla, Tuzla, Bosnia & Herceg..
    Zenic, Natasa
    Univ Split, Split, Croatia.
    Ostojic, Ljerka
    Univ Mostar, Mostar, Bosnia & Herceg.; Univ Split, Split, Croatia; Acad Med Sci, Sarajevo, Bosnia & Herceg..
    Zubak, Ivana
    Univ Zadar, Zadar, Croatia.
    Jelicic, Mario
    Univ Split, Split, Croatia.
    Pojskic, Haris
    Mittuniversitetet, Fakulteten för humanvetenskap, Avdelningen för hälsovetenskap. Linnaeus Univ, Kalmar.
    Are Sports-Related Factors Correlated to the Prevalence and Initiation of Illicit Drug Misuse in Adolescence?: Prospective Study in Older Adolescents2018Inngår i: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, artikkel-id 1236284Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Sport participation is considered as a factor of potential influence on illicit drugmisuse (IDM) in adolescence, but there is an evident lack of studies which prospectively investigated this problem. This study aimed to prospectively investigate the sports-related factors related to IDM and the initiation of IDM among older adolescents. The participants were 436 adolescents (202 females; 16 years old at study baseline). They were tested at baseline and follow-up (two years later). The predictors included variables associated with different facets of sports participation and success in sports. The criteria were (i) baseline IDM, (ii) follow-up IDM, and (iii) initiation of IDM between baseline and follow-up. Crude and adjusted (controlled for parental conflict, age, socioeconomic status, and gender) logistic regressions were applied to establish correlations between predictors and criteria. There were higher odds for baseline IDM in adolescents who quit individual sports (OR: 4.2, 95% CI: 1.3-13.9), who had better competitive sports achievements (OR: 1.8, 95% CI: 1.0-3.3), and those involved in sports for a longer time (OR: 1.6, 95% CI: 1.0-2.5). The IDM at follow-up was more prevalent in adolescents who were involved in sports for a longer time (OR: 1.7, 95% CI: 1.1-2.6). Initiation of drug use was predicted by longer experience in sports (OR: 1.8, 95% CI: 1.1-3.1). Sports-related factors were more negatively than positively related to illicit drug use. Most probably, the transition from junior to senior level in sports put specific stress on those adolescents who were highly committed to sports until that time, but who then had to question their own sports abilities and future potential in sports. Sport-authorities should be informed on established results and specific public-health efforts aimed at preventing IDM in athletic adolescents are urgently needed.

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