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Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis
Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences.
Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences.ORCID iD: 0000-0002-5108-6487
AlbaNova Univ Ctr, KTH Royal Inst Technol, Sch Biotechnol, Div Ind Biotechnol, SE-10691 Stockholm, Sweden.
Stockholm Univ, Dept Mat & Environm Chem, Berzelii Ctr EXSELENT Porous Mat, S-10691 Stockholm, Sweden.ORCID iD: 0000-0001-7286-1211
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2016 (English)In: ACS Catalysis, ISSN 2155-5435, E-ISSN 2155-5435, Vol. 6, no 6, 3932-3940 p.Article in journal (Refereed) Published
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Abstract [en]

Organic synthesis is in general performed using stepwise transformations where isolation and purification of key intermediates is often required prior to further reactions. Herein we disclose the concept of integrated heterogeneous metal/enzymatic multiple relay catalysis for eco-friendly and asymmetric synthesis of valuable molecules (e.g., amines and amides) in one-pot using a combination of heterogeneous metal and enzyme catalysts. Here reagents, catalysts, and different conditions can be introduced throughout the one-pot procedure involving multistep catalytic tandem operations. Several novel cocatalytic relay sequences (reductive amination/amidation, aerobic oxidation/reductive amination/amidation, reductive amination/kinetic resolution and reductive amination/ dynamic kinetic resolution) were developed. They were next applied to the direct synthesis of various biologically and optically active amines or amides in one-pot from simple aldehydes, ketones, or alcohols, respectively.

Place, publisher, year, edition, pages
2016. Vol. 6, no 6, 3932-3940 p.
Keyword [en]
heterogeneous metal, enzyme, reductive amination, relay catalysis, heterogeneous catalysis, tandem reactions, kinetic resolution, dynamic kinetic resolution
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:miun:diva-28476DOI: 10.1021/acscatal.6b01031ISI: 000377326700066Scopus ID: 2-s2.0-84973911460OAI: oai:DiVA.org:miun-28476DiVA: diva2:949605
Available from: 2016-07-21 Created: 2016-07-21 Last updated: 2016-09-29Bibliographically approved

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Afewerki, SamsonTai, Cheuk-WaiBerglund, PerCordova, Armando
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