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Skeletal muscle fiber characteristics and oxidative capacity in hemiparetic stroke survivors
Aarhus Univ Hosp, Dept Neurol, Noerrebrogade 44, DK-8000 Aarhus C, Denmark.
Aarhus Univ, Sect Sport Sci, Dept Publ Hlth, DK-8000 Aarhus C, Denmark.
Aarhus Univ, Sect Sport Sci, Dept Publ Hlth, DK-8000 Aarhus C, Denmark.
Aarhus Univ, Hammel Neurorehabil & Res Ctr, DK-8000 Aarhus C, Denmark.
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2016 (English)In: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 53, no 5, 748-754 p.Article in journal (Refereed) Published
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Abstract [en]

Introduction: Skeletal muscle is changed after stroke, but conflicting data exist concerning muscle morphology and oxidative enzyme capacity. Methods: In 36 chronic stroke patients bilateral rectus femoris muscle biopsies were analyzed, and fiber type proportions and cross-sectional areas were determined by ATPase histochemistry. Enzymatic concentrations of citrate synthase (CS) and 3-Hydroxyacyl-coenzymeA-dehydrogenase (HAD) were determined using freeze-dried muscle tissue. Findings were correlated with clinical outcomes. Results: In the paretic muscles the mean fiber area was smaller (P=0.0004), and a lower proportion of type 1 fibers (P=0.0016) and a higher proportion of type 2X fibers (P=0.0002) were observed. The paretic muscle had lower CS (P=0.013) and HAD concentrations (P=0.037). Mean fiber area correlated with muscle strength (r=0.43; P=0.041), and CS concentration correlated with aerobic capacity (r=0.47; P=0.01). Conclusions: In stroke survivors there is a phenotypic shift toward more fatigable muscle fibers with reduced oxidative enzymatic capacity that relates to clinical outcomes. Muscle Nerve53: 748-754, 2016

Place, publisher, year, edition, pages
2016. Vol. 53, no 5, 748-754 p.
Keyword [en]
histological techniques [E01, 370, 225, 750], immunohistochemistry [E01, 370, 225, 750, 551, 512], motor activity [G11, 427, 590, 530, 698], muscle fibers, skeletal [A10, 690, 552, 500, 500], paresis [C10, 597, 636], staining and labeling [E01, 370, 225, 500, 620, 670], stroke [C10, 228, 140, 300, 775]
National Category
Sport and Fitness Sciences Physiology
Identifiers
URN: urn:nbn:se:miun:diva-27808DOI: 10.1002/mus.24907ISI: 000375116300012PubMedID: 26361074Scopus ID: 2-s2.0-84963622923OAI: oai:DiVA.org:miun-27808DiVA: diva2:934348
Available from: 2016-06-08 Created: 2016-06-07 Last updated: 2016-06-08Bibliographically approved

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