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X-ray deconvolution microscopy
Tech Univ Munich, Phys Dept, Lehrstuhl Biomed Phys, James Franck Str, D-85748 Garching, Germany.
Tech Univ Munich, Phys Dept, Lehrstuhl Biomed Phys, James Franck Str, D-85748 Garching, Germany.
Tech Univ Munich, Phys Dept, Lehrstuhl Biomed Phys, James Franck Str, D-85748 Garching, Germany.
Deutsch Elektronen Synchrotron DESY, Notkestr 85, D-22607 Hamburg, Germany.
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2016 (English)In: Biomedical Optics Express, ISSN 2156-7085, E-ISSN 2156-7085, Vol. 7, no 4, 1227-1239 p.Article in journal (Refereed) Published
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Text
Abstract [en]

Recent advances in single-photon-counting detectors are enabling the development of novel approaches to reach micrometer-scale resolution in x-ray imaging. One example of such a technology are the MEDIPIX3RX-based detectors, such as the LAMBDA which can be operated with a small pixel size in combination with real-time on-chip charge-sharing correction. This characteristic results in a close to ideal, box-like point spread function which we made use of in this study. The proposed method is based on raster-scanning the sample with sub-pixel sized steps in front of the detector. Subsequently, a deconvolution algorithm is employed to compensate for blurring introduced by the overlap of pixels with a well defined point spread function during the raster-scanning. The presented approach utilizes standard laboratory x-ray equipment while we report resolutions close to 10 mu m. The achieved resolution is shown to follow the relationship p/n with the pixel-size p of the detector and the number of raster-scanning steps n. (C) 2016 Optical Society of America

Place, publisher, year, edition, pages
2016. Vol. 7, no 4, 1227-1239 p.
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:miun:diva-27812DOI: 10.1364/BOE.7.001227ISI: 000373778900012Scopus ID: 2-s2.0-84962905907Local ID: STCOAI: oai:DiVA.org:miun-27812DiVA: diva2:934307
Available from: 2016-06-08 Created: 2016-06-07 Last updated: 2017-08-09Bibliographically approved

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Graafsma, Heinz
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CiteExportLink to record
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Citation style
  • apa
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