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Endurance Exercise Enhances the Effect of Strength Training on Muscle Fiber Size and Protein Expression of Akt and mTOR
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. (NVC)
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. (NVC)
Swedish Sch Sport & Hlth Sci, Stockholm, Sweden.ORCID iD: 0000-0003-3747-0148
Swedish Sch Sport & Hlth Sci, Stockholm, Sweden.
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2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 2, e0149082Article in journal (Refereed) Published
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Abstract [en]

Reports concerning the effect of endurance exercise on the anabolic response to strength training have been contradictory. This study re-investigated this issue, focusing on training effects on indicators of protein synthesis and degradation. Two groups of male subjects performed 7 weeks of resistance exercise alone (R; n = 7) or in combination with preceding endurance exercise, including both continuous and interval cycling (ER; n = 9). Muscle biopsies were taken before and after the training period. Similar increases in leg-press 1 repetition maximum (30%; P< 0.05) were observed in both groups, whereas maximal oxygen uptake was elevated (8%; P< 0.05) only in the ER group. The ER training enlarged the areas of both type I and type II fibers, whereas the R protocol increased only the type II fibers. The mean fiber area increased by 28% (P< 0.05) in the ER group, whereas no significant increase was observed in the R group. Moreover, expression of Akt and mTOR protein was enhanced in the ER group, whereas only the level of mTOR was elevated following R training. Training-induced alterations in the levels of both Akt and mTOR protein were correlated to changes in type I fiber area (r = 0.55-0.61, P< 0.05), as well as mean fiber area (r = 0.55-0.61, P< 0.05), reflecting the important role played by these proteins in connection with muscle hypertrophy. Both training regimes reduced the level of MAFbx protein (P< 0.05) and tended to elevate that of MuRF-1. The present findings indicate that the larger hypertrophy observed in the ER group is due more to pronounced stimulation of anabolic rather than inhibition of catabolic processes.

Place, publisher, year, edition, pages
2016. Vol. 11, no 2, e0149082
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Sport and Fitness Sciences
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URN: urn:nbn:se:miun:diva-27816DOI: 10.1371/journal.pone.0149082ISI: 000371218400061PubMedID: 26885978Scopus ID: 2-s2.0-84960336508OAI: oai:DiVA.org:miun-27816DiVA: diva2:934283
Available from: 2016-06-08 Created: 2016-06-07 Last updated: 2017-04-04Bibliographically approved

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Kazior, ZuzannaWillis, Sarah J.Moberg, MarcusHolmberg, Hans-Christer
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