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Acute dietary nitrate supplementation improves arterial endothelial function at high altitude: A double-blinded randomized controlled cross over study
Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, Fac Med, KG Jebsen Ctr Exercise Med, N-7006 Trondheim, Norway..
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. ;LHL Hlth, LHL Klinikkene Raros, Roros, Norway..
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. (Swedish Winter Sports Research Center)
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2015 (English)In: Nitric oxide, ISSN 1089-8603, E-ISSN 1089-8611, Vol. 50, p. 58-64Article in journal (Refereed) Published
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Abstract [en]

Introduction: Dietary nitrate (NO3-) supplementation serves as an exogenous source of nitrite (NO3-) and nitric oxide (NO) through the NO3- NO3- NO pathway, and may improve vascular functions during normoxia. The effects of NO3- supplementation in healthy lowlanders during hypobaric hypoxia are unknown. Purpose: Determine the effect of acute oral NO3- supplementation via beetroot juice (BJ) on endothelial function (flow mediated dilation; FMD) in lowlanders at 3700 m. Methods: FMD was measured using ultrasound and Doppler in the brachial artery of 11 healthy subjects (4 females, age 25 +/- 5 yrs; height 1.8 +/- 0.1 m, weight 72 +/- 10 kg) sojourning to high altitude. In a randomized, double-blinded crossover study design, FMD was measured 3 h after drinking BJ (5.0 mmol NO3-) and placebo (PL; 0.003 mmol No-3(-)) supplementation at 3700 m, with a 24-h wash out period between tests. FMD was also measured without any BJ supplementation pre-trek at 1370 m, after 5 days at 4200 m and upon return to 1370 m after 4 weeks of altitude exposure (above 2500 m). The altitude exposure was interrupted by a decent to lower altitude where subjects spent two nights at 1370 m before returning to altitude again. Results: Ten subjects completed the NO3- supplementation. FMD (mean +/- SD) pre-trek value was 6.53 +/- 2.32% at 1370 m. At 3700 m FMD was reduced to 3.84 +/- 1.31% (p < 0.01) after PL supplementation but was normalized after receiving BJ (5.77 +/- 1.14% (p = 1.00). Eight of the subjects completed the interrupted 4-week altitude stay, and their FMD was lower at 4200 m (FMD 3.04 +/- 2.22%) and at post-altitude exposure to 1370 m (FMD 3.91 +/- 2.58%) compared to pre-trek FMD at 1370 m. Conclusion: Acute dietary NO3- supplementation may abolish altitude-induced reduction in endothelial function, and can serve as a dietary strategy to ensure peripheral vascular function in lowland subjects entering high altitude environments. (C) 2015 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
2015. Vol. 50, p. 58-64
Keyword [en]
Nitric oxide, Beetroot juice, Field-study, FMD, Flow mediated dilation, Nepal, Altitude medicine
National Category
Health Sciences
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URN: urn:nbn:se:miun:diva-26568DOI: 10.1016/j.niox.2015.08.006ISI: 000363362900008Scopus ID: 2-s2.0-84941336858OAI: oai:DiVA.org:miun-26568DiVA: diva2:883416
Available from: 2015-12-17 Created: 2015-12-17 Last updated: 2017-12-01Bibliographically approved

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Engan, HaraldPatrician, AlexanderSchagatay, Erika

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