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Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden .
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden .
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden .
Mid Sweden University, Faculty of Human Sciences, Department of Psychology. Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom .ORCID iD: 0000-0003-1209-8802
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2014 (English)In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 43, no 1, 83-90 p.Article in journal (Refereed) Published
Abstract [en]

Methods We conducted a population-based cohort study via linkage of Swedish national and regional registers to investigate maternal pre-pregnancy BMI (underweight: BMI < 18.5; overweight: 25 BMI < 30; obesity: BMI epsilon 30) in relation to offspring ADHD. We followed 673 632 individuals born in Sweden between 1992 and 2000, with prospectively collected information on maternal pre-pregnancy BMI, until they received an ADHD diagnosis or ADHD medication, death, emigration or 31 December 2009. Hazard ratios (HRs) were estimated by Cox proportional hazards models. Stratified Cox proportional hazards models were applied to data on full siblings to control for unmeasured familial confounding. Results At the population level, pre-pregnancy overweight/obesity was associated with increased risk of offspring ADHD (HRoverweight = 1.23, 95% CI = 1.18-1.27, P = 0.01; HRobesity = 1.64, 95% CI = 1.57-1.73, P = 0.01), after adjustment for measured covariates. In full sibling comparisons, however, previously observed associations no longer remained (HRoverweight = 0.98, 95% CI = 0.83-1.16, P = 0.82; HRobesity = 1.15, 95% CI = 0.85-1.56, P = 0.38). Conclusions The results suggested that the association between maternal pre-pregnancy overweight/obesity and offspring ADHD could be ascribed to unmeasured familial confounding.

Place, publisher, year, edition, pages
2014. Vol. 43, no 1, 83-90 p.
Keyword [en]
ADHD, maternal BMI, prenatal, confounding, sibling comparison
National Category
Psychology Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:miun:diva-21993DOI: 10.1093/ije/dyt152ISI: 000332341300016Scopus ID: 2-s2.0-84896894290OAI: oai:DiVA.org:miun-21993DiVA: diva2:721591
Available from: 2014-06-04 Created: 2014-05-28 Last updated: 2016-12-02Bibliographically approved

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CiteExportLink to record
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Citation style
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