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Doublet discharge stimulation increases sarcoplasmic reticulum Ca2+ release and improves performance during fatiguing contractions in mouse muscle fibres
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden .
Institute of Movement Sciences and Sports Medicine, Medicine Faculty, Geneva University, Geneva, Switzerland .
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden .
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.ORCID iD: 0000-0002-3814-6246
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2013 (English)In: Journal of Physiology, ISSN 0022-3751, E-ISSN 1469-7793, Vol. 591, no 15, 3739-3748 p.Article in journal (Refereed) Published
Abstract [en]

Double discharges (doublets) of motor neurones at the onset of contractions increase both force and rate of force development during voluntary submaximal contractions. The purpose of this study was to examine the role of doublet discharges on force and myoplasmic free [Ca2+] ([Ca2+](i)) during repeated fatiguing contractions, using a stimulation protocol mimicking the in vivo activation pattern during running. Individual intact fibres from the flexor digitorum brevis muscle of mice were stimulated at 33 degrees C to undergo 150 constant-frequency (five pulses at 70 Hz) or doublet (an initial, extra pulse at 200 Hz) contractions at 300 ms intervals. In the unfatigued state, doublet stimulation resulted in a transient (approximate to 10 ms) approximate doubling of [Ca2+](i), which was accompanied by a greater force-time integral (approximate to 70%) and peak force (approximate to 40%) compared to constant frequency contractions. Moreover, doublets markedly increased force-time integral and peak force during the first 25 contractions of the fatiguing stimulation. In later stages of fatigue, addition of doublets increased force production but the increase in force production corresponded to only a minor portion of the fatigue-induced reduction in force. In conclusion, double discharges at the onset of contractions effectively increase force production, especially in early stages of fatigue. This beneficial effect occurs without additional force loss in later stages of fatigue, indicating that the additional energy cost induced by doublet discharges to skeletal muscle is limited.

Place, publisher, year, edition, pages
2013. Vol. 591, no 15, 3739-3748 p.
National Category
Sport and Fitness Sciences
Identifiers
URN: urn:nbn:se:miun:diva-19920DOI: 10.1113/jphysiol.2013.257188ISI: 000322990000010Scopus ID: 2-s2.0-84881024821OAI: oai:DiVA.org:miun-19920DiVA: diva2:655483
Available from: 2013-10-11 Created: 2013-09-25 Last updated: 2013-10-11Bibliographically approved

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CiteExportLink to record
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