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Hypercoagulability in acute bleeding peptic ulcer disease assessed by thrombin-antithrombin III concentrations.
Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences. Department of Surgery, Sundsvall County Hospital, Sundsvall, Sweden .
Department of Surgery, Sundsvall County Hospital, Sundsvall, Sweden .
Department of Surgery, Sundsvall County Hospital, Sundsvall, Sweden .
1993 (English)In: European Journal of Surgery, ISSN 1102-4151, E-ISSN 1741-9271, Vol. 159, no 3, 167-9 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To find out whether patients with acute bleeding peptic ulcers have hypercoagulable blood.

DESIGN: Prospective open study.

SETTING: District hospital in Sweden.

SUBJECTS: 54 consecutive patients with duodenal ulcer (n = 25) and gastric ulcer (n = 29) admitted with haematemesis or melaena, or both.

INTERVENTIONS: Diagnosis verified on admission by endoscopy, and healing was examined at follow up. Consumption of non-steroidal anti-inflammatory drugs, and smoking habits, were recorded.

MAIN OUTCOME MEASURES: Coagulation of the blood monitored by concentrations of plasma thrombin-antithrombin III (TAT) complex in samples obtained on admission for the acute bleeding episode and at follow up 1-2 months later.

RESULTS: The plasma TAT complex concentrations were raised during the acute bleeding episode (p < 0.001) compared with an age matched reference group. The TAT complex concentrations measured at follow up had returned to the reference range in all patients, whether or not their ulcers had healed.

CONCLUSION: The results indicate that patients with acute haemorrhage from peptic ulcers have hypercoagulable blood during the acute episode.

Place, publisher, year, edition, pages
1993. Vol. 159, no 3, 167-9 p.
Keyword [en]
Gastrointestinal haemorrhage, Hypercoagulation, Thrombin-antithrombin III complex
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:miun:diva-19097ISI: A1993LG92100008PubMedID: 8102892Scopus ID: 0027231661OAI: oai:DiVA.org:miun-19097DiVA: diva2:647419
Available from: 2013-09-11 Created: 2013-06-07 Last updated: 2017-01-12Bibliographically approved

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CiteExportLink to record
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