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Influence of haemorrhage and blood transfusion on haemostasis. An experimental study in rabbits.
Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences. Department of Surgery, Sundsvall County Hospital, S-851 86 Sundsvall, Sweden .
Department of Surgery, Sundsvall County Hospital, S-851 86 Sundsvall, Sweden .
Department of Surgery, Sundsvall County Hospital, S-851 86 Sundsvall, Sweden .
Department of Surgery, Sundsvall County Hospital, S-851 86 Sundsvall, Sweden .
1995 (English)In: Vox Sanguinis, ISSN 0042-9007, E-ISSN 1423-0410, Vol. 68, no 2, p. 100-4Article in journal (Refereed) Published
Abstract [en]

The influence of haemorrhage and blood transfusion on primary haemostasis, coagulation and fibrinolysis was investigated in rabbits. Acute loss of 20% of the blood volume gave a significantly shortened coagulation time (Lee-White method) but no detectable change in fibrinolysis (euglobulin clot lysis time) and primary haemostasis (primary haemostatic plug formation time in transected arterioles in rabbit mesenteric microcirculation). Acute loss of 20% of blood volume followed by blood transfusion resulted in a prolonged coagulation time and also in a prolonged primary haemostatic plug formation time, but no change in fibrinolysis. It could be concluded that the haemorrhage did not affect the platelet-dependent primary haemostasis but resulted in a shortened coagulation time. Blood transfusion seemed to affect adversely both the primary haemostasis and the shortened coagulation time induced by haemorrhage.

Place, publisher, year, edition, pages
1995. Vol. 68, no 2, p. 100-4
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:miun:diva-19099PubMedID: 7762215Scopus ID: 0028917976OAI: oai:DiVA.org:miun-19099DiVA, id: diva2:647398
Available from: 2013-09-11 Created: 2013-06-07 Last updated: 2017-12-06Bibliographically approved

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