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Work stress and risk of cancer: meta-analysis of 5700 incident cancer events in 116 000 European men and women
Finnish Institute of Occupational Health, 00250 Helsinki, Finland.
Finnish Institute of Occupational Health, 00250 Helsinki, Finland.
Stress Research Institute, Stockholm University, Stockholm, Sweden.
Stress Research Institute, Stockholm University, Stockholm, Sweden.
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2013 (English)In: BMJ. British Medical Journal, ISSN 0959-535X, E-ISSN 1756-1833, Vol. 346, Art. no. f165- p.Article in journal (Refereed) Published
Abstract [en]

Objective To investigate whether work related stress, measured and defined as job strain, is associated with the overall risk of cancer and the risk of colorectal, lung, breast, or prostate cancers. Design Meta-analysis of pooled prospective individual participant data from 12 European cohort studies including 116 056 men and women aged 17-70 who were free from cancer at study baseline and were followed-up for a median of 12 years. Work stress was measured and defined as job strain, which was self reported at baseline. Incident cancers (all n=5765, colorectal cancer n=522, lung cancer n=374, breast cancer n=1010, prostate cancer n=865) were ascertained from cancer, hospital admission, and death registers. Data were analysed in each study with Cox regression and the study specific estimates pooled in meta-analyses. Models were adjusted for age, sex, socioeconomic position, body mass index (BMI), smoking, and alcohol intake Results A harmonised measure of work stress, high job strain, was not associated with overall risk of cancer (hazard ratio 0.97, 95% confidence interval 0.90 to 1.04) in the multivariable adjusted analyses. Similarly, no association was observed between job strain and the risk of colorectal (1.16, 0.90 to 1.48), lung (1.17, 0.88 to 1.54), breast (0.97, 0.82 to 1.14), or prostate (0.86, 0.68 to 1.09) cancers. There was no clear evidence for an association between the categories of job strain and the risk of cancer. Conclusions These findings suggest that work related stress, measured and defined as job strain, at baseline is unlikely to be an important risk factor for colorectal, lung, breast, or prostate cancers.

Place, publisher, year, edition, pages
2013. Vol. 346, Art. no. f165- p.
Keyword [en]
adolescent; aged; alcohol consumption; article; body mass; breast cancer; cancer incidence; cancer risk; colorectal cancer; controlled study; Europe; female; follow up; hospital admission; human; job stress; lung cancer; major clinical study; male; men's health; priority journal; prostate cancer; risk assessment; self report; smoking habit; social status; women's health
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:miun:diva-18647DOI: 10.1136/bmj.f165ISI: 000314807100002Scopus ID: 2-s2.0-84874328130OAI: oai:DiVA.org:miun-18647DiVA: diva2:613513
Available from: 2013-04-04 Created: 2013-03-27 Last updated: 2013-04-09Bibliographically approved

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