miun.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Interventions for HIV-associated nephropathy
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.
Save the Youth Initiative, PO Box 3951, Kaduna North, Kaduna, Nigeria.
Save the Youth Initiative, PO Box 3951, Kaduna North, Kaduna, Nigeria.
2013 (English)In: Cochrane Database of Systematic Reviews, ISSN 1469-493X, E-ISSN 1469-493X, no 1, p. Art. no. CD007183-Article, review/survey (Refereed) Published
Abstract [en]

Background Human immunodeficiency virus-associated nephropathy (HIVAN) is the most common cause of end stage kidney disease (ESKD) in human immunodeficiency virus-1 (HIV-1) serotype patients and it mostly affects patients of African descent. It rapidly progresses to ESKD if untreated. The goal of treatment is directed toward reducing HIV-1 replication and/or slowing the progression of chronic kidney disease. The following pharmacological agents have been used for the treatment of HIVAN: antiretroviral therapy, angiotensin-converting enzyme inhibitors (ACEi), steroids and recently cyclosporin. Despite this, the effect of each intervention is yet to be evaluated. Objectives To evaluate the benefits and harms of adjunctive therapies in the management of HIVAN and its effects on symptom severity and all-cause mortality. Search methods In January 2012 we searched the Cochrane Renal Group's Specialised Register, AIDS Education Global Information System (AEGIS database), ClinicalTrial.gov, the WHO International Clinical Trials Registry Portal, and reference lists of retrieved articles without language restrictions. In our original review we searched CENTRAL, MEDLINE, EMBASE, and AIDSearch, in addition to contacting individual researchers, research organisations and pharmaceutical companies. Selection criteria Randomised controlled trials (RCTs) and quasi-RCTs of any therapy used in the treatment of HIVAN. Data collection and analysis We independently screened the search outputs for relevant studies and to retrieve full articles when necessary. For dichotomous outcomes results were to be expressed as risk ratios with 95% confidence intervals, and for continuous scales of measurement the mean difference was to be used. Main results We identified four relevant ongoing studies: one is still ongoing; two have completed recruitment but are yet to be published; and the fourth study was suspended for unspecified reasons. No completed RCTs or quasi-RCTs were identified. We summarised and tabulated the data from the observational studies, however no formal analyses were performed. Authors' conclusions There is currently no RCT-based evidence upon which to base guidelines for the treatment of HIVAN, however three ongoing studies have been identified. Data from observational studies suggest steroids and angiotensin-converting enzyme inhibitors appear to improve kidney function in patients with HIVAN, however no formal analyses were performed in this review. This review highlights the need for good quality RCTs to address the effects of interventions for treating this group.

Place, publisher, year, edition, pages
2013. no 1, p. Art. no. CD007183-
Keywords [en]
AIDS-Associated Nephropathy [therapy], Humans
National Category
Public Health, Global Health, Social Medicine and Epidemiology Infectious Medicine Urology and Nephrology
Identifiers
URN: urn:nbn:se:miun:diva-18648DOI: 10.1002/14651858.CD007183.pub3ISI: 000314315800033Scopus ID: 2-s2.0-84938493396OAI: oai:DiVA.org:miun-18648DiVA, id: diva2:613474
Available from: 2013-03-28 Created: 2013-03-27 Last updated: 2018-02-20Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textScopusInterventions for HIV-associated nephropathy (Cochrane Review)

Authority records BETA

Yahaya, Ismail

Search in DiVA

By author/editor
Yahaya, Ismail
By organisation
Department of Health Sciences
In the same journal
Cochrane Database of Systematic Reviews
Public Health, Global Health, Social Medicine and EpidemiologyInfectious MedicineUrology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 61 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf