miun.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Carbon nanomaterials as drug carriers: Real time drug release investigation
Mid Sweden University, Faculty of Science, Technology and Media, Department of applied science and design.ORCID iD: 0000-0003-2873-7875
Mid Sweden University, Faculty of Science, Technology and Media, Department of applied science and design.ORCID iD: 0000-0001-7329-3359
2012 (English)In: Materials science & engineering. C, biomimetic materials, sensors and systems, ISSN 0928-4931, Vol. 32, no 5, 1247-1252 p.Article in journal (Refereed) Published
Abstract [en]

The use of carbon nanomaterials in biomedical applications and the cytotoxicity of these materials have been areas of great interest during the last decade. In vitro drug load and release, as well as in vivo animal tests, have been carried out using carbon nanomaterials. However, no comparison studies on the drug load and the release of different carbon nanomaterials have been reported. Here, we report on a real time investigation of the drug release of carbon black (CB) nanoparticles, carbon nanotubes (CNTs) and graphene oxide (GO), using rhodamine B (RB) as a model of drug. The binding of RB to the nanomaterials were characterized by FTIR and UV-vis. The mass loading capacities of these nanomaterials were also studied, showing that GO had the highest capacity. The real time drug release experiment indicated different accumulative release modes of these nanomaterials at different pH values, due to their different binding modes with RB, which is also discussed as being the reason for the mechanism differences. Moreover, the comparison of the drug release capacity of CNT-RB and f-CNT-RB (functionalized-CNT-RB) indicated an influence of hydrogen bonds in both drug loading and release, as the hydrogen bonds increased the loading capacity of the carbon nanotube after acid treatment and changed the drug release mechanism at pH 7.4. Thus, here we identified the drug release modes of the different carbon nanomaterials. The results of the influence of functional groups and hydrogen bonds point also out a potential way of controlling the drug release behavior of carbon nanomaterials by surface modification. © 2012 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
2012. Vol. 32, no 5, 1247-1252 p.
Keyword [en]
Carbon black; Carbon nanotube; Drug release; Graphene oxide; pH influence
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:miun:diva-16714DOI: 10.1016/j.msec.2012.03.016ISI: 000305716300035Scopus ID: 2-s2.0-84861526955OAI: oai:DiVA.org:miun-16714DiVA: diva2:546128
Available from: 2012-08-22 Created: 2012-08-17 Last updated: 2015-07-01Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopushttp://www.scopus.com/inward/record.url?eid=2-s2.0-84861526955&partnerID=40&md5=6eddf26a48b054d1b40d8365ff8ad95b

Search in DiVA

By author/editor
Zhang, RenyunOlin, Håkan
By organisation
Department of applied science and design
In the same journal
Materials science & engineering. C, biomimetic materials, sensors and systems
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 796 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf