The discussion paper highlights challenges for the travel and tourism industry provoked by new information and communication technologies (ICTS) as well as related veins of e-Business research. First of all, the paper explores stylized facts from the last 15 years of web history in tourism and delineates actual levels of ICT adoption in tourism. Moreover, behavioural and structural changes on account of ICT in tourism are explained by adopting a multi-disciplinary approach. Finally, an innovative ICT application from tourism practice the destination guide www.dolomitiSuperski.mobi is portrayed. In the outlook the paper sketches the future of e-Tourism research by highlighting the interrelation between computer, information and management sciences.