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Human skeletal muscle glycogen utilization in exhaustive exercise: Role of subcellular localization and fibre type
Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences.ORCID iD: 0000-0002-3814-6246
Institute of Pathology, University of Southern Denmark, Odense, Denmark.
Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark .
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2011 (English)In: Journal of Physiology, ISSN 0022-3751, E-ISSN 1469-7793, Vol. 589, no 11, 2871-2885 p.Article in journal (Refereed) Published
Abstract [en]

Although glycogen is known to be heterogeneously distributed within skeletal muscle cells, there is presently little information available about the role of fibre types, utilization and resynthesis during and after exercise with respect to glycogen localization. Here, we tested the hypothesis that utilization of glycogen with different subcellular localizations during exhaustive arm and leg exercise differs and examined the influence of fibre type and carbohydrate availability on its subsequent resynthesis. When 10 elite endurance athletes (22 ± 1 years, = 68 ± 5 ml kg-1 min-1, mean ± SD) performed one hour of exhaustive arm and leg exercise, transmission electron microscopy revealed more pronounced depletion of intramyofibrillar than of intermyofibrillar and subsarcolemmal glycogen. This phenomenon was the same for type I and II fibres, although at rest prior to exercise, the former contained more intramyofibrillar and subsarcolemmal glycogen than the latter. In highly glycogen-depleted fibres, the remaining small intermyofibrillar and subsarcolemmal glycogen particles were often found to cluster in groupings. In the recovery period, when the athletes received either a carbohydrate-rich meal or only water the impaired resynthesis of glycogen with water alone was associated primarily with intramyofibrillar glycogen. In conclusion, after prolonged high-intensity exercise the depletion of glycogen is dependent on subcellular localization. In addition, the localization of glycogen appears to be influenced by fibre type prior to exercise, as well as carbohydrate availability during the subsequent period of recovery. These findings provide insight into the significance of fibre type-specific compartmentalization of glycogen metabolism in skeletal muscle during exercise and subsequent recovery. © 2011 The Authors. Journal compilation © 2011 The Physiological Society.

Place, publisher, year, edition, pages
2011. Vol. 589, no 11, 2871-2885 p.
Keyword [en]
carbohydrate, glycogen, water, adult, arm exercise, arm muscle, article, athlete, carbohydrate diet, cellular distribution, controlled study, glycogen metabolism, glycogen muscle level, glycogen utilization, human, human experiment, human tissue, leg exercise, leg muscle, male, muscle cell, normal human, oxygen consumption, priority journal, transmission electron microscopy
National Category
Sport and Fitness Sciences
Identifiers
URN: urn:nbn:se:miun:diva-14202DOI: 10.1113/jphysiol.2010.204487Scopus ID: 2-s2.0-79957821940OAI: oai:DiVA.org:miun-14202DiVA: diva2:431431
Available from: 2011-07-19 Created: 2011-07-19 Last updated: 2012-08-14Bibliographically approved

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