miun.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
RNA folding argues against a hot-start origin of life
Mid Sweden University, Faculty of Science, Technology and Media, Department of Engineering, Physics and Mathematics.
Show others and affiliations
2000 (English)In: Journal of Molecular Evolution, ISSN 0022-2844, E-ISSN 1432-1432, Vol. 51, no 4, 416-421 p.Article in journal (Other academic) Published
Abstract [en]

Opinion is strongly divided on whether life arose on earth under hot or cold conditions, the hot-start and cold-start Scenarios, respectively. The origin of life close to deep thermal vents appears as the majority opinion among biologists, but there is considerable biochemical evidence that high temperatures are incompatible with an RNA world. To be functional, RNA has to fold into a three-dimensional structure. We report both theoretical and experimental results on RNA folding and show that las expected) hot conditions strongly reduce RNA folding. The theoretical results come from energy-minimization calculations of the average extent of folding of RNA, mainly from 0-90 degreesC, for both random sequences and tRNA sequences. The experimental results are from circular-dichroism measurements of tRNA over a similar range of temperatures. The quantitative agreement between calculations and experiment is remarkable, even to the shape of the curves indicating the cooperative nature of RNA folding and unfolding. These results provide additional evidence for a lower temperature stage being necessary in the origin of life.

Place, publisher, year, edition, pages
2000. Vol. 51, no 4, 416-421 p.
Keyword [en]
circular dichroism, origin of life, RNA folding, RNA secondary, structure, RNA world, posttranscriptional modification, secondary structure, common ancestor, hyperthermophiles, eukaryotes, evolution, bacteria, tree
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:miun:diva-13717ISI: 000090055700012OAI: oai:DiVA.org:miun-13717DiVA: diva2:413251
Note
LetterAvailable from: 2011-04-28 Created: 2011-04-28 Last updated: 2011-05-29Bibliographically approved

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Moulton, Vincent
By organisation
Department of Engineering, Physics and Mathematics
In the same journal
Journal of Molecular Evolution
Biochemistry and Molecular Biology

Search outside of DiVA

GoogleGoogle Scholar

Total: 29 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf