Complexity is still challenging human efforts of comprehension and development. This despite considerable research advancements including Interpretive Structural Modelling (ISM), Systemic Modelling (SyM), System Matrix Methodology (SMM), Variety Management (VM), and many others. However, by combining those results in different ways further ways of improving human complexity handling are found. Two main development streams are identified as constituting the base for such a progress. First, advances in systemic research on complexity have provided us with the necessary theoretical and conceptual tools. Next, rapid improvements in computer and information technology have created quite new conditions for support of human intellectual work. Therefore, finally the potential of Computer Aided Systems Theory (CAST) for support of human complexity challenges will be assessed.