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Hypoxia augments apnea-induced increase in hematocrit and hemoglobin concentration
Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences, Engineering and Mathematics.
Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences, Engineering and Mathematics.
Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences, Engineering and Mathematics.
Responsible organisation
2009 (English)In: European Journal of Applied Physiology, ISSN 1439-6319, E-ISSN 1439-6327, Vol. 105, no 1, 63-68 p.Article in journal (Refereed) Published
Abstract [en]

Increased hemoglobin concentration (Hb) and hematocrit (Hct) attributable to spleen contraction raises blood gas storage capacity during apnea, but the mechanisms that trigger this response have not been clarified. We focused on the role of hypoxia in triggering these Hb and Hct elevations. After horizontal rest for 20 min, 10 volunteers performed 3 maximal apneas spaced by 2 min, each preceded by a deep inspiration of air. The series was repeated using the same apneic durations but after 1 min of 100% oxygen breathing and oxygen inspiration prior to apneas. Mean apneic durations were 150s, 171s, and 214s for apneas 1, 2, and 3, respectively. Relative to pre-apnea values, the mean post-apneic arterial oxygen saturation nadir was 84.7% after air and 98% after oxygen. A more pronounced elevation of both Hb and Hct occurred during the air trial: after apnea 1 with air, mean Hb had increased by 1.5% (P<0.01), but no clear increase was found after the first apnea in with oxygen. After the third apnea with air Hb had increased by 3.0% (P<0.01), and with oxygen by 2.0% (P<0.01). After the first apnea with air Hct had increased by 1.9% (P<0.01) and after 3 apneas by 3.0% (P<0.01), but Hct did not change significantly in the oxygen trial. In both trials, Hb and Hct were at pre-apneic levels 10 min after apneas. Diving bradycardia during apnea was the same in both trials. We concluded that hypoxia is essential in inducing spleen-related Hb and Hct increase during apnea.

Place, publisher, year, edition, pages
2009. Vol. 105, no 1, 63-68 p.
Keyword [en]
Breath-hold, apnea, hematocrit, spleen contraction, diving response, diving reflex
National Category
Biological Sciences Microbiology
Identifiers
URN: urn:nbn:se:miun:diva-4364DOI: 10.1007/s00421-008-0873-9ISI: 000262411500010PubMedID: 18839204Scopus ID: 2-s2.0-58549090876Local ID: 5598OAI: oai:DiVA.org:miun-4364DiVA: diva2:29396
Available from: 2008-11-29 Created: 2008-11-29 Last updated: 2016-09-26Bibliographically approved
In thesis
1. Hematological changes arising from spleen contraction during apnea and altitude in humans
Open this publication in new window or tab >>Hematological changes arising from spleen contraction during apnea and altitude in humans
2008 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Östersund: Mid Sweden University, 2008. 49 p.
Series
Mid Sweden University doctoral thesis, ISSN 1652-893X ; 57
Keyword
Hypoxia, hypercapnia, hemoglobin, hematocrit, breath-hold diving
National Category
Microbiology Sport and Fitness Sciences Physiology
Identifiers
urn:nbn:se:miun:diva-7786 (URN)978-91-86073-03-9 (ISBN)
Public defence
(English)
Supervisors
Available from: 2009-07-09 Created: 2008-12-15 Last updated: 2009-07-09Bibliographically approved

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CiteExportLink to record
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Citation style
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