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Phosphate buffers in capillary electrophoresis/mass spectrometry using atmospheric pressure photo ionization and electrospray ionization
Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences.ORCID iD: 0000-0002-3646-294X
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2003 (English)In: Rapid Communication in mass spectrometry, ISSN 0951-4198, Vol. 17, no 20, 2267-2272 p.Article in journal (Refereed) Published
Abstract [en]

Capillary electrophoresis (CE) has been combined with atmospheric pressure photoionization (APPI) and electrospray ionization (ESI) for mass spectrometric (MS) detection. Separation conditions using potassium phosphate buffer and ammonium formate buffer have been compared for analysis of eleven pharmaceutical bases. The results showed improvements in separation efficiency and peak symmetry when phosphate buffer was used. The low flow in CE may enable utilization of these advances with MS detection. Compared with ESI, the APPI technique provided a cluster-free background. The enhanced signal-to-noise ratio in the total ion current (TIC) and the reduced spectral background indicated that the APPI process is less affected by non-volatile salts in the CE buffers. This results in a wider range of choice of CE buffers in CE/MS analysis when APPI is the ionization method.

Place, publisher, year, edition, pages
2003. Vol. 17, no 20, 2267-2272 p.
Keyword [en]
APPI
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:miun:diva-2509DOI: 10.1002/rcm.1182Local ID: 1766OAI: oai:DiVA.org:miun-2509DiVA: diva2:27541
Available from: 2008-09-30 Created: 2008-09-30 Last updated: 2011-01-10Bibliographically approved

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