Purpose. This study aimed to investigate the relationship between interpersonal sensitivity and relational aggression with the mediating role of resilience in married people with multiple sclerosis (MS). Materials and methods. This research was a cross-sectional analytical correlation study. In this study, 234 people with MS were selected by convenience sampling method and responded to the research questionnaires. In order to collect data, the couple relationship aggression and victimization scale (CRAViS), interpersonal sensitivity scale (IPSM), and resilience scale (CD-RISC) were used. Results. The results showed that the proposed model has good processing (2/df=1.29, CFI=.98, RMSEA=.03). Path analysis results showed that interpersonal sensitivity didn't have a significant direct effect on communicative aggression (β=.132, p=.096); But interpersonal sensitivity has a negative and significant effect on resilience (β=-.803, p=.001) and resilience has a negative and significant effect (β=-.575, p=.001) on communicative aggression. Based on this, it can be said that resilience plays a full mediating role between interpersonal sensitivity and relational aggression (β=.461, p=.001). Conclusion. Overall, it can be concluded that interpersonal sensitivity, due to its negative on resilience, can increase aggressive behaviors in people who suffer from MS, based on this, the implementation of educational and therapeutic in-terventions for the Improvement of interpersonal sensitivity and resilience is suggested.