Multilevel thresholding is one of the principal methods of image segmentation. These methods enjoy image histogram for segmentation. The quality of segmentation depends on the value of the selected thresholds. Since an exhaustive search is made for finding the optimum value of the objective function, the conventional methods of multilevel thresholding are time-consuming computationally, especially when the number of thresholds increases. Use of evolutionary algorithms has attracted a lot of attention under such circumstances. Human mental search algorithm is a population-based evolutionary algorithm inspired by the manner of human mental search in online auctions. This algorithm has three interesting operators: (1) clustering for finding the promising areas, (2) mental search for exploring the surrounding of every solution using Levy distribution, and (3) moving the solutions toward the promising area. In the present study, multilevel thresholding is proposed for image segmentation using human mental search algorithm. Kapur (entropy) and Otsu (between-class variance) criteria were used for this purpose. The advantages of the proposed method are described using twelve images and in comparison with other existing approaches, including genetic algorithm, particle swarm optimization, differential evolution, firefly algorithm, bat algorithm, gravitational search algorithm, and teaching-learning-based optimization. The obtained results indicated that the proposed method is highly efficient in multilevel image thresholding in terms of objective function value, peak signal to noise, structural similarity index, feature similarity index, and the curse of dimensionality. In addition, two nonparametric statistical tests verified the efficiency of the proposed algorithm, statistically.