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Modeling of the mechanobiological adaptation in muscular arteries
2017 (English)In: European journal of mechanics. A, Solids, ISSN 0997-7538, E-ISSN 1873-7285, Vol. 64, p. 165-177Article in journal (Refereed) Published
Abstract [en]

The growth and remodeling of arteries, as controlled by the local stress state and the sensory input from the endothelial cells of the artery wall, is given a novel theoretical framework incorporating the active behavior of vascular smooth muscle. We show that local sensory input maps uniquely to the ratio between a target arterial wall cross-section area corresponding to homeostatic conditions and the current arterial wall area. A growth law is formulated by taking the production rates of individual constituents of the arterial wall to be functions of this target-to-current wall area ratio. We find that a minimum active stress response of vascular smooth muscle is necessary to achieve stable adaptation of the artery wall to dynamic flow conditions. With a sufficient active stress alteration in response to stretch, stable growth toward a homeostatic state can be observed for finite step changes or ramp changes in the transmural pressure or the flow rate.

Place, publisher, year, edition, pages
2017. Vol. 64, p. 165-177
Identifiers
URN: urn:nbn:se:miun:diva-48645DOI: 10.1016/j.euromechsol.2017.01.011OAI: oai:DiVA.org:miun-48645DiVA, id: diva2:1776500
Available from: 2023-06-28 Created: 2023-06-28 Last updated: 2023-06-28Bibliographically approved

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Lindström, S. B.
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