There is an extensive need for continued research about how employees work environment and health are affected in epidemics and pandemics. The Covid-19 pandemic pushed many employees away from their offices into their homes. The main aim of this study is to investigate the relationships between working from home, work/life conflict, and mental wellbeing in Europe during the pandemic by analyzing the following research questions: How have hours worked from home, work-to-life conflict, life-to-work conflict and mental wellbeing changed during different phases of the pandemic? How are hours worked from home related to work-to-life conflict and life-to-work conflict respectively? How are hours worked from home, work-to-life conflict and life-to-work related to mental wellbeing? The study is based on a large-scale online survey that took place at three occasions during the Covid-19 pandemic, between summer 2020 and spring 2022, in 27 EU countries. Entitled, “Living, working and COVID-19”, the aim was to investigate the impact of the pandemic on wellbeing, work and the financial situation of individuals across the EU. Work-to-life conflict and Life-to-work conflict is measured through two separate indexes and Mental wellbeing is measured by the WHO-5 mental wellbeing index.Results indicate that hours worked from home and mental wellbeing decreased, and work-life conflict and life-to-work conflict increased, between 2020 and 2022. Hours worked from home is significantly negatively correlated with work-to-life conflict but significantly positively correlated with life-to-work conflict. This means that the more hours worked from home the less work-to-life conflict and the more life-to-work conflict. There are significant negative relationships between both these two last variables and mental wellbeing; the higher the conflict, the lower mental wellbeing.