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Nanomedicine and nanoparticle-based delivery systems in plastic and reconstructive surgery
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2023 (English)In: Maxillofacial Plastic and Reconstructive Surgery, ISSN 2288-8586, Vol. 45, no 1, article id 15Article, review/survey (Refereed) Published
Abstract [en]

Background: Nanotechnology and nanomedicine are rising novel fields in plastic and reconstructive surgery (PRS). The use of nanomaterials often goes with regenerative medicine. Due to their nanoscale, these materials stimulate repair at the cellular and molecular levels. Nanomaterials may be placed as components of nanocomposite polymers allowing enhancement of overall biochemical and biomechanical properties with improved scaffold properties, cellular attachment, and tissue regeneration. They may also be formulated as nanoparticle-based delivery systems for controlled release of signal factors or antimicrobials, for example. However, more studies on nanoparticle-based delivery systems still need to be done in this field. Nanomaterials are also used as frameworks for nerves, tendons, and other soft tissues. Main body: In this mini-review, we focus on nanoparticle-based delivery systems and nanoparticles targeting cells for response and regeneration in PRS. Specifically, we investigate their roles in various tissue regeneration, skin and wound healing, and infection control. Cell surface-targeted, controlled-release, and inorganic nanoparticle formulations with inherent biological properties have enabled enhanced wound healing, tumor visualization/imaging, tissue viability, and decreased infection, and graft/transplantation rejection through immunosuppression. Conclusions: Nanomedicine is also now being applied with electronics, theranostics, and advanced bioengineering technologies. Overall, it is a promising field that can improve patient clinical outcomes in PRS. 

Place, publisher, year, edition, pages
2023. Vol. 45, no 1, article id 15
Keywords [en]
Delivery systems, Nanomedicine, Nanotechnology, Plastic surgery, Reconstructive surgery, Regenerative medicine
National Category
Biomaterials Science
Identifiers
URN: urn:nbn:se:miun:diva-48173DOI: 10.1186/s40902-023-00383-9ISI: 000960218900001Scopus ID: 2-s2.0-85151650564OAI: oai:DiVA.org:miun-48173DiVA, id: diva2:1751703
Available from: 2023-04-19 Created: 2023-04-19 Last updated: 2023-04-20Bibliographically approved

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Lee, Ka Yiu

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CiteExportLink to record
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Citation style
  • apa
  • ieee
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  • de-DE
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