Hip joints can be damaged by metabolic (degenerative disease) or mechanical (fracture) causes, limiting their functioning. To restore joint movement, the joint must be replaced by a hip prosthesis. Lubrication, friction and wear phenomena occur in the joints, which, in turn, are often responsible for the failure of the prosthesis, causing its loosening. The aim of the present study is to evaluate the biotribological behavior of a prototype Ti6Al4V hip prosthesis made-up by electron beam melting (EBM) additive manufacturing and subsequently surface modified by anodizing. Once the prototype was obtained, some samples were polished for biotribological tests and others for anodizing. The biotribological tests were performed in a ball-ondisk tribometer using 6 mm diameter alumina counterbodies. Wear tracks of 2 mm in diameter were obtained, using SBF solution at a temperature of 37 °C as the medium. The samples fabricated by EBM and subsequently anodized showed the highest values of friction coefficients, while the samples madeup by forging and EBM showed similar friction coefficients, while the anodized samples showed the lowest wear rate followed by the samples manufactured by EBM.