Nature-based tourism is a highly dynamic sector and subject to many trends and changes. Based on a comprehensive literature review, this chapter identifies broad global changes, so-called megatrends, that affect tourism in general and NBT in particular. Data from an online panel survey with experts from five countries who were asked to recognize the most prominent nature-based tourism trends in a 10 years’ perspective, is analyzed in the light of global drivers. The chapter concludes that issues related to sustainability, health and well-being, increased specialization and segmentation are the most noticeable and recurrent trends in nature-based tourism today.