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Expression of programmed death-1 (CD279) in primary cutaneous B-cell lymphomas with correlation to lymphoma entities and biological behaviour
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2013 (English)In: British Journal of Dermatology, ISSN 0007-0963, E-ISSN 1365-2133, Vol. 169, no 6, p. 1212-1218Article in journal (Refereed) Published
Abstract [en]

Background Programmed death-1 (PD-1/CD279) is a cell-surface protein expressed in activated T cells and a subset of T lymphocytes including follicular helper T cells (TFH). The interaction between PD-1 and its ligands plays a role in immune response and evasion of malignancies. In nodal follicular lymphoma, the number of intratumoral PD-1-positive lymphocytes is associated with overall survival. Objectives To investigate 28 cases of primary cutaneous B-cell lymphoma, including the subtypes PCFCL (n = 10), PCMZL (n = 10) and DLBCL-LT (n = 8) for the number and density of PD-1-positive cells. Methods Immunohistochemical staining and a computerized morphometric analysis for evaluation were applied. The results were correlated with the clinical outcome. To distinguish between activated T cells and TFH we performed PD-1/bcl-6 double staining and compared these results with CXCL-13 staining. Double staining for PD-1 and PAX-5 was used to investigate whether tumour cells were positive for PD-1. Results The PD-1-positive cells represented tumour-infiltrating T cells (TILs). Only a minor subset was represented by TFH. Patients with DLBCL-LT had a significantly lower number of PD-1-positive TILs than those with PCMZL (P = 0·012) and PCFCL (P = 0·002) or both (P = 0·001). The difference between PCMZL and PCFCL did not reach significance (P = 0·074). The tumour cells were negative for PD-1. Conclusions A higher number of PD-1-expressing cells was found in indolent PCMZL and PCFCL than in high-malignant DLBCL-LT. The PD-1-positive cells represented not only TFH, but also other activated T cells as a part of the tumour microenvironment. The tumour cells in all investigated types of PCBCL did not show aberrant PD-1 expression. What’s already known about this topic? In nodal follicular lymphoma, the number of intratumoral programmed death (PD)-1-positive lymphocytes is associated with overall survival. No data exist for primary cutaneous B-cell lymphoma (PCBCL). What does this study add? A higher number of PD-1-expressing cells was found in indolent primary cutaneous marginal zone lymphoma and primary cutaneous follicle centre lymphoma, in contrast to the more aggressive diffuse large B-cell lymphoma, leg type. PD-1-positive cells do not represent only follicular helper T cells. The tumour cells in all investigated types of PCBCL did not show aberrant PD-1 expression. © 2013 British Association of Dermatologists.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2013. Vol. 169, no 6, p. 1212-1218
Keywords [en]
programmed death 1 receptor, transcription factor PAX5, CD3 antigen, programmed death 1 receptor, adult, article, B cell lymphoma, cancer cell, CD3+ T lymphocyte, cell infiltration, clinical article, female, human, human tissue, immunohistochemistry, large cell lymphoma, male, polymerase chain reaction, priority journal, protein expression, skin lymphoma, T lymphocyte, B cell lymphoma, follicular lymphoma, germinal center, helper cell, metabolism, middle aged, pathology, skin tumor, tumor associated leukocyte, Antigens, CD3, Female, Germinal Center, Humans, Immunohistochemistry, Lymphocytes, Tumor-Infiltrating, Lymphoma, B-Cell, Lymphoma, Follicular, Male, Middle Aged, Programmed Cell Death 1 Receptor, Skin Neoplasms, T-Lymphocytes, Helper-Inducer
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:miun:diva-44516DOI: 10.1111/bjd.12579Scopus ID: 2-s2.0-84888997783OAI: oai:DiVA.org:miun-44516DiVA, id: diva2:1642048
Available from: 2022-03-03 Created: 2022-03-03 Last updated: 2022-03-03Bibliographically approved

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Pfaltz, Monique C.

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