CD123-positive plasmacytoid dendritic cells in primary cutaneous marginal zone b-cell lymphoma: Diagnostic and pathogenetic implications
2009 (English)In: American Journal of Surgical Pathology, ISSN 0147-5185, E-ISSN 1532-0979, Vol. 33, no 9, p. 1307-1313Article in journal (Refereed) Published
Abstract [en]
The histogenesis of primary cutaneous marginal zone B-cell lymphoma (PCMZL) has not yet been clarified. Plasmacytoid dendritic cells (PDC) play a crucial role in the initiation of immune responses and activation of T-cells and B-cells. We analyzed the presence of PDC by immunohistochemistry in various forms of primary cutaneous B-cell lymphomas and in B-cell pseudolymphomas. Clusters of CD123 PDC were observed in all PCMZL (23 of 23 cases; 100%) and in two-thirds of cutaneous B-cell pseudolymphomas (14 of 22; 64%), but only in a minority of primary cutaneous follicle center lymphoma (4 of 31; 13%) and not in primary cutaneous diffuse large B-cell lymphoma, leg type. CD123+ PDC clusters were found in close proximity to monoclonal plasma cells and T-cells and were already present at high numbers in early lesions and initial recurrences of PCMZL. In conclusion, the detection of larger clusters of PDC in PCMZL provides a useful adjunctive diagnostic marker and suggests a pathogenetically relevant role of these cells in PCMZL. Furthermore, the occurrence of PDC could explain the high number of T-cells typically found in PCMZL. We propose considering PCMZL as a unique and potentially antigen-driven neoplasm with PDC, T-cells, and B-cells as the constitutive tumor components. Copyright © 2009 by Lippincott Williams & Wilkins.
Place, publisher, year, edition, pages
2009. Vol. 33, no 9, p. 1307-1313
Keywords [en]
CD123 antigen, article, B cell lymphoma, cancer cell, cancer diagnosis, clinical article, dendritic cell, human, immune response, immunohistochemistry, marginal zone lymphoma, plasma cell, plasmacytoid dendritic cell, primary tumor, pseudolymphoma, T lymphocyte, Clone Cells, Dendritic Cells, Gene Rearrangement, B-Lymphocyte, Light Chain, Humans, Immunoenzyme Techniques, Immunoglobulin Light Chains, Interleukin-3 Receptor alpha Subunit, Lymph Nodes, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Plasma Cells, Polymerase Chain Reaction, Skin Neoplasms, Tumor Markers, Biological
National Category
Rheumatology and Autoimmunity
Identifiers
URN: urn:nbn:se:miun:diva-44501DOI: 10.1097/PAS.0b013e3181a6ae1eScopus ID: 2-s2.0-70249107534OAI: oai:DiVA.org:miun-44501DiVA, id: diva2:1642020
2022-03-032022-03-032022-03-03Bibliographically approved