The transmission of medical data and the possibility for distant healthcare structures to share experiments about a given medical case raises several conceptual and technical questions. Good remote healthcare monitoring deals with more problems in personalized heath data processing compared to the traditional methods nowadays used in several parts of hospitals in the world. The adoption of telemedicine in the healthcare sector has significantly changed medical collaboration. However, to provide good telemedicine services through new technologies such as cloud computing, cloud storage, and so on, a suitable and adaptable framework should be designed. Moreover, in the chain of medical information exchange, between requesting agencies, including physicians, a secure and collaborative platform enhanced the decision-making process. This paper provides an in-depth literature review on the interaction that telemedicine has with cloud-based computing. On the other hand, the paper proposes a framework that can allow various research organizations, healthcare sectors, and government agencies to log data, develop collaborative analysis, and support decision-making. The electrocardiogram (ECG) and electroencephalogram EEG case studies demonstrate the benefit of the proposed approach in data reduction and high-fidelity signal processing to a local level; this can make possible the extracted characteristic features to be communicated to the cloud database. © 2021 International Measurement Confederation (IMEKO). All rights reserved.