Integrative system analysis requires a tool that facilitates both an investigation of systems from a holistic perspective and research that scrutinizes particular aspects of a specific system while retaining a holistic understanding. This paper proposes such a tool – a novel, multi-perspective kaleidoscope that constitutes a conceptual framework for integrative system analysis. This theoretical frame of reference synthesizes the results of a previous literature analysis that yielded a detailed conceptualization of the terms system, infrastructure and governance in the realm of critical infrastructure protection (CIP). The multi-perspective kaleidoscope for integrative system analysis (KISA) considers four perspectives: system, infrastructure, process and governance. These four perspectives are founded on three layers that mirror the ability of the perspectives to adjust the special focus on the micro, meso or macro level of a system of interest. The presented KISA model contributes a systemic perspective that can guide the exploration of complex issues in society to acquire beneficial, multi-faceted knowledge and a multi-perspective understanding. The integrative system perspective that this study originates will be a valuable tool for a variety of assessments in the context CIP and beyond.