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Association between amygdala reactivity and a dopamine transporter gene polymorphism
Department of Pharmacology, University of Gothenburg, Gothenburg, Sweden.
Department of Psychology, Uppsala University, Uppsala, Sweden.ORCID iD: 0000-0002-6355-660x
Department of Psychology, Uppsala University, Uppsala, Sweden.
PET Centre, UppsalaUniversity Hospital and Department of Nuclear Medicine and PET, Uppsala University, Uppsala, Sweden.
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2014 (English)In: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 4, article id e420Article in journal (Refereed) Published
Abstract [en]

Essential for detection of relevant external stimuli and for fear processing, the amygdala is under modulatory influence of dopamine (DA). The DA transporter (DAT) is of fundamental importance for the regulation of DA transmission by mediating reuptake inactivation of extracellular DA. This study examined if a common functional variable number tandem repeat polymorphism in the 3' untranslated region of the DAT gene (SLC6A3) influences amygdala function during the processing of aversive emotional stimuli. Amygdala reactivity was examined by comparing regional cerebral blood flow, measured with positron emission tomography and [(15)O]water, during exposure to angry and neutral faces, respectively, in a Swedish sample comprising 32 patients with social anxiety disorder and 17 healthy volunteers. In a separate US sample, comprising 85 healthy volunteers studied with blood oxygen level-dependent functional magnetic resonance imaging, amygdala reactivity was assessed by comparing the activity during exposure to threatening faces and neutral geometric shapes, respectively. In both the Swedish and the US sample, 9-repeat carriers displayed higher amygdala reactivity than 10-repeat homozygotes. The results suggest that this polymorphism contributes to individual variability in amygdala reactivity.

Place, publisher, year, edition, pages
Nature Publishing Group, 2014. Vol. 4, article id e420
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Neurosciences
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URN: urn:nbn:se:miun:diva-38890DOI: 10.1038/tp.2014.50ISI: 000344826900001PubMedID: 25093598Scopus ID: 2-s2.0-84907307114OAI: oai:DiVA.org:miun-38890DiVA, id: diva2:1423373
Available from: 2020-04-14 Created: 2020-04-14 Last updated: 2020-05-08Bibliographically approved

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