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Human serotonin transporter availability predicts fear conditioning
Department of Psychology, Uppsala University, Uppsala, Sweden; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.ORCID iD: 0000-0002-6355-660X
Department of Psychology, Uppsala University, Uppsala, Sweden.
Department of Psychology, Uppsala University, Uppsala, Sweden.
Department of Psychology, Uppsala University, Uppsala, Sweden; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
2015 (English)In: International Journal of Psychophysiology, ISSN 0167-8760, E-ISSN 1872-7697, Vol. 98, no 3 Pt 2, p. 515-9, article id S0167-8760(14)01664-XArticle in journal (Refereed) Published
Abstract [en]

Serotonin facilitates fear learning in animals. We therefore predicted that individual differences in the capacity to regulate serotonergic transmission in the human neural fear circuit would be inversely related to fear conditioning. The capacity to regulate serotonergic transmission was indexed by serotonin transporter availability measured with [(11)C]-DASB positron emission tomography. Results indicate that lower serotonin transporter availability in the amygdala, insula and dorsal anterior cingulate cortex predicts enhanced conditioned autonomic fear responses. Our finding supports serotonergic modulation of fear conditioning in humans and may aid in understanding susceptibility for developing anxiety conditions such as post-traumatic stress disorder.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 98, no 3 Pt 2, p. 515-9, article id S0167-8760(14)01664-X
Keywords [en]
5-HTT, Amygdala, Anterior cingulate, Anxiety disorders, DASB, Insula, Post-traumatic stress disorder
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:miun:diva-38889DOI: 10.1016/j.ijpsycho.2014.12.002ISI: 000367493700004PubMedID: 25498766Scopus ID: 2-s2.0-84949532661OAI: oai:DiVA.org:miun-38889DiVA, id: diva2:1423372
Available from: 2020-04-14 Created: 2020-04-14 Last updated: 2020-04-24Bibliographically approved

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CiteExportLink to record
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