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Myotilin - a prominent marker of myofibrillar remodelling
Umeå University.
Mid Sweden University, Faculty of Science, Technology and Media, Department of Natural Sciences.
Biomedicum Helsinki, Finland.
University of Turku, Turku University Central Hospital, Finland.
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2007 (English)In: Neuromuscular Disorders, ISSN 0960-8966, E-ISSN 1873-2364, Vol. 17, no 1, 61-68 p.Article in journal (Refereed) Published
Abstract [en]

Myofibrillar remodelling with insertion of sarcomeres is a typical feature of biopsies taken from persons suffering of exercise-induced delayed onset muscle soreness. Here we studied the presence of the sarcomeric protein myotilin in eccentric exercise related lesions. Myotilin is a component of sarcomeric Z-discs and it binds several other Z-disc proteins, i.e. alpha-actinin, filamin C, F-actin and FATZ. Myotilin has previously been shown to be present in nemaline rods and central cores and to be mutated in limb girdle muscular dystrophy 1A (LGMD1A) and in a subset of myofibrillar myopathies, indicating an important role in Z-disc maintenance. Our findings on non-diseased muscle affected by eccentric exercise give new information on how myotilin is associated to myofibrillar components upon remodelling. We show that myotilin was present in increased amount in lesions related to Z-disc streaming and events leading to insertion of new sarcomeres in pre-existing myofibrils and can therefore be used as a marker for myofibrillar remodelling. Interestingly, myotilin is preferentially associated with F-actin rather than with the core Z-disc protein alpha-actinin during these events. This suggests that myotilin has a key role in the dynamic molecular events mediating myofibrillar assembly in normal and diseased skeletal muscle.

Place, publisher, year, edition, pages
2007. Vol. 17, no 1, 61-68 p.
Keyword [en]
DOMS, Eccentric exercise, Z-disc streaming
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:miun:diva-8473DOI: 10.1016/j.nmd.2006.09.007ISI: 000244575300009Scopus ID: 2-s2.0-33846849263OAI: oai:DiVA.org:miun-8473DiVA: diva2:139834
Available from: 2009-01-26 Created: 2009-01-26 Last updated: 2017-12-14Bibliographically approved

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Yu, Ji-Guo

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