Environmental governance is a challenge for many developing countries, and soil pollution is typically overlooked by authorities in the Global South. Soil governance should protect people and environment from the hazards of pollution and promote sustainable remediation of polluted sites through legislation and soil policies that facilitate the use of appropriate technology. Today, however, the soil governance landscape is highly fragmented and often fails to adequately address these concerns. Combining soil remediation with profitable activities (alone or in combination) such as food and fiber production, biomass energy production, erosion control, carbon sequestration, favoring biodiversity, etc. is potentially an appropriate strategy to promote the decontamination of polluted agriculture soil in low-income countries. Many potential pitfalls follow such a strategy but decision support tools may provide insights from the latest scientific remediation findings to stakeholders in their exploration of policy options. This chapter explores challenges and opportunities for sustainable soil governance in developing countries.