miun.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Resistance Training Induces Antiatherogenic Effects on Metabolomic Pathways
National Institute for Health and Welfare, Helsinki, Finland; University of Helsinki, Helsinki, Finland.
University of Jyväskylä, Jyväskylä, Finland.
University of Jyväskylä, Jyväskylä, Finland; University of Helsinki, Helsinki, Finland.
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. University of Jyväskylä, Jyväskylä, Finland. (Swedish Winter Sports Research Centre)
Show others and affiliations
2019 (English)In: Medicine & Science in Sports & Exercise, ISSN 0195-9131, E-ISSN 1530-0315, Vol. 51, no 9, p. 1866-1875Article in journal (Refereed) Published
Abstract [en]

Introduction Arising evidence suggests that resistance training has the potential to induce beneficial modulation of biomarker profile. To date, however, only immediate responses to resistance training have been investigated using high-throughput metabolomics whereas the effects of chronic resistance training on biomarker profile have not been studied in detail. Methods A total of 86 recreationally active healthy men without previous systematic resistance training background were allocated into (i) a resistance training (RT) group (n = 68; age, 33 ± 7 yr; body mass index, 28 ± 3 kg·m-2) and (ii) a non-RT group (n = 18; age, 31 ± 4 yr; body mass index, 27 ± 3 kg·m-2). Blood samples were collected at baseline (PRE), after 4 wk (POST-4wk), and after 16 wk of resistance training intervention (POST-16wk), as well as baseline and after the non-RT period (20-24 wk). Nuclear magnetic resonance-metabolome platform was used to determine metabolomic responses to chronic resistance training. Results Overall, the resistance training intervention resulted in favorable alterations (P < 0.05) in body composition with increased levels of lean mass (2.8%), decreased levels of android (9.6%), and total fat mass (7.5%). These changes in body composition were accompanied by antiatherogenic alterations in serum metabolome profile (false discovery rate < 0.05) as reductions in non-high-density lipoprotein cholesterol (e.g., free cholesterol, remnant cholesterol, intermediate-density lipoprotein cholesterols, low-density lipoprotein cholesterols) and related apolipoprotein B, and increments in conjugated linoleic fatty acids levels were observed. Individuals with the poorest baseline status (i.e., body composition, metabolome profile) benefitted the most from the resistance training intervention. Conclusions In conclusion, resistance training improves cardiometabolic risk factors and serum metabolome even in previously healthy young men. Thus, suggesting attenuated risk for future cardiovascular disease. 

Place, publisher, year, edition, pages
2019. Vol. 51, no 9, p. 1866-1875
Keywords [en]
Amino Acids, Biomarkers, Cardiovascular Disease, Lipids, Omics, Resistance Exercise
National Category
Health Sciences
Identifiers
URN: urn:nbn:se:miun:diva-37011DOI: 10.1249/MSS.0000000000002003ISI: 000484228600010PubMedID: 30973481Scopus ID: 2-s2.0-85070820732OAI: oai:DiVA.org:miun-37011DiVA, id: diva2:1347848
Available from: 2019-09-02 Created: 2019-09-02 Last updated: 2019-09-30Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Ihalainen, Johanna K.

Search in DiVA

By author/editor
Ihalainen, Johanna K.
By organisation
Department of Health Sciences
In the same journal
Medicine & Science in Sports & Exercise
Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 10 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf