miun.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Marine Polysaccharide-Collagen Coatings on Ti6Al4V Alloy Formed by Self-Assembly
Univ Lancaster, Lancaster, England.ORCID iD: 0000-0001-5583-8298
Natl Res Tomsk Polytech Univ, Tomsk, Russia.
IFREMER, Nantes, France.
IFREMER, Nantes, France.ORCID iD: 0000-0002-2449-5410
Show others and affiliations
2019 (English)In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666X, Vol. 10, no 1, article id 68Article in journal (Refereed) Published
Abstract [en]

Polysaccharides of marine origin are gaining interest as biomaterial components. Bacteria derived from deep-sea hydrothermal vents can produce sulfated exopolysaccharides (EPS), which can influence cell behavior. The use of such polysaccharides as components of organic, collagen fibril-based coatings on biomaterial surfaces remains unexplored. In this study, collagen fibril coatings enriched with HE800 and GY785 EPS derivatives were deposited on titanium alloy (Ti6Al4V) scaffolds produced by rapid prototyping and subjected to physicochemical and cell biological characterization. Coatings were formed by a self-assembly process whereby polysaccharides were added to acidic collagen molecule solution, followed by neutralization to induced self-assembly of collagen fibrils. Fibril formation resulted in collagen hydrogel formation. Hydrogels formed directly on Ti6Al4V surfaces, and fibrils adsorbed onto the surface. Scanning electron microscopy (SEM) analysis of collagen fibril coatings revealed association of polysaccharides with fibrils. Cell biological characterization revealed good cell adhesion and growth on bare Ti6Al4V surfaces, as well as coatings of collagen fibrils only and collagen fibrils enhanced with HE800 and GY785 EPS derivatives. Hence, the use of both EPS derivatives as coating components is feasible. Further work should focus on cell differentiation.

Place, publisher, year, edition, pages
2019. Vol. 10, no 1, article id 68
National Category
Mechanical Engineering
Identifiers
URN: urn:nbn:se:miun:diva-35809DOI: 10.3390/mi10010068ISI: 000459735300067PubMedID: 30669427OAI: oai:DiVA.org:miun-35809DiVA, id: diva2:1297105
Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-03-19Bibliographically approved

Open Access in DiVA

fulltext(1603 kB)133 downloads
File information
File name FULLTEXT01.pdfFile size 1603 kBChecksum SHA-512
c9146e05e85e7102c41da66cc8c707bdea8e08cc2445b7b839370a18070462c0621df1772b8d2edebd2dc139e5c65952874ac52ddb4059d36254b6b1c5f9cbe8
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Koptioug, Andrei

Search in DiVA

By author/editor
Norris, KarlColliec-Jouault, SylviaSinquin, CorinneKoptioug, AndreiSurmenev, Roman A.Douglas, Timothy E. L.
By organisation
Department of Quality Management and Mechanical Engineering
In the same journal
Micromachines
Mechanical Engineering

Search outside of DiVA

GoogleGoogle Scholar
Total: 133 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 131 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf