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Pectin coatings on titanium alloy scaffolds produced by additive manufacturing: Promotion of human bone marrow stromal cell proliferation
Lancaster University, United Kingdom.
Technische Universität Dresden, Germany.
AGH University of Science and Technology, Kraków, Poland.
National Institute for Optoelectronics, Romania; National Research Tomsk Polytechnic University, Russia.
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2018 (English)In: Materials letters (General ed.), ISSN 0167-577X, E-ISSN 1873-4979, Vol. 227, p. 225-228Article in journal (Refereed) Published
Abstract [en]

Ti6Al4V is a popular biomaterial for load-bearing implants for bone contact, which can be fabricated by additive manufacturing technologies. Their long-term success depends on their stable anchoring in surrounding bone, which in turn depends on formation of new bone tissue on the implant surface, for which adhesion and proliferation of bone-forming cells is a pre-requisite. Hence, surface coatings which promote cell adhesion and proliferation are desirable. Here, Ti6Al4V discs prepared by additive manufacturing (EBM) were coated with layers of pectins, calcium-binding polysaccharides derived from citrus (C) and apple (A), which also contained alkaline phosphatase (ALP), the enzyme responsible for mineralization of bone tissue. Adhesion and proliferation of human bone marrow stromal cells (hBMSC) were assessed. Proliferation after 7 days was increased by A-ALP coatings and, in particular, by C-ALP coatings. Cell morphology was similar on coated and uncoated samples. In conclusion, ALP-loaded pectin coatings promote hBMSC adhesion and proliferation. 

Place, publisher, year, edition, pages
2018. Vol. 227, p. 225-228
Keywords [en]
Biomaterials, Biomimetic, Thin films
National Category
Mechanical Engineering
Identifiers
URN: urn:nbn:se:miun:diva-34113DOI: 10.1016/j.matlet.2018.05.060ISI: 000436420200059Scopus ID: 2-s2.0-85047304412OAI: oai:DiVA.org:miun-34113DiVA, id: diva2:1230746
Available from: 2018-07-04 Created: 2018-07-04 Last updated: 2018-08-13Bibliographically approved

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Koptioug, Andrei

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