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N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. Lund University. (Swedish Winter Sports Research Centre)
University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Lund University.
Lund University.
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, no 1, article id 3016Article in journal (Refereed) Published
Abstract [en]

Obesity is a major health problem, and although caloric restriction and exercise are successful strategies to lose adipose tissue in obese individuals, a simultaneous decrease in skeletal muscle mass, negatively effects metabolism and muscle function. To deeper understand molecular events occurring in muscle during weight-loss, we measured the expressional change in human skeletal muscle following a combination of severe caloric restriction and exercise over 4 days in 15 Swedish men. Key metabolic genes were regulated after the intervention, indicating a shift from carbohydrate to fat metabolism. Nicotinamide N-methyltransferase (NNMT) was the most consistently upregulated gene following the energy-deficit exercise. Circulating levels of N1-methylnicotinamide (MNA), the product of NNMT activity, were doubled after the intervention. The fasting-fed state was an important determinant of plasma MNA levels, peaking at ~18 h of fasting and being lowest ~3 h after a meal. In culture, MNA was secreted by isolated human myotubes and stimulated lipolysis directly, with no effect on glucagon or insulin secretion. We propose that MNA is a novel myokine that enhances the utilization of energy stores in response to low muscle energy availability. Future research should focus on applying MNA as a biomarker to identify individuals with metabolic disturbances at an early stage. 

Place, publisher, year, edition, pages
2018. Vol. 8, no 1, article id 3016
National Category
Sport and Fitness Sciences
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URN: urn:nbn:se:miun:diva-33265DOI: 10.1038/s41598-018-21099-1ISI: 000424985800054PubMedID: 29445118Scopus ID: 2-s2.0-85042133592OAI: oai:DiVA.org:miun-33265DiVA, id: diva2:1190458
Available from: 2018-03-14 Created: 2018-03-14 Last updated: 2018-03-19Bibliographically approved

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Ström, KristofferHolmberg, Hans-Christer

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