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High heart rate reactors display greater decreases in tear SIgA concentration following a novel acute stressor
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. Bangor University, Gwynedd, UK. (Swedish Winter Sports Research Centre)ORCID iD: 0000-0002-5381-736X
Bangor University, Gwynedd, UK. (Extremes Research Group)
Bangor University, Gwynedd, UK. (Insitute for the Psychology of Elite Performance)
Bangor University, Gwynedd, UK. (Extremes Research Group)
2018 (English)In: Biological Psychology, ISSN 0301-0511, E-ISSN 1873-6246, Vol. 133, p. 85-88Article in journal (Refereed) Published
Abstract [en]

Tear secretory immunoglobulin-A (SIgA) is a putative biomarker of common-cold risk with potential utility in non-invasive diagnostics. As SIgA secretion at the ocular surface is under strong autonomic control, we investigated the relationship between HR reactivity and tear SIgA responses to novel experiential stress. Thirty-two healthy participants undertook a 60-second zip-line ride to evoke acute stress and a seated-rest control trial in a randomised-crossover design. We recorded heart rate (HR) continuously and collected unstimulated tear samples 5-min-pre-, 2-min-post- and 20-min-post-stress/control. Stress increased HR and state anxiety whereas tear SIgA concentration decreased 44% post-stress vs. control. Higher peak HR values during stress uniquely explained 21% of the variance in tear SIgA reactivity to stress (p < .01); high HR reactors displayed greater decreases in tear SIgA concentration. We conclude that physiological arousal increases immune reactivity to acute stress and highlight tear SIgA as a minimally-invasive, physiologically relevant biomarker of immune reactivity.

Place, publisher, year, edition, pages
2018. Vol. 133, p. 85-88
Keywords [en]
Biomarkers, Tears, Noninvasive measures, Immunity, Stress reactivity, Immune reactivity, State anxiety, Acute stress, Psychological stress
National Category
Physiology
Identifiers
URN: urn:nbn:se:miun:diva-32815DOI: 10.1016/j.biopsycho.2018.02.002ISI: 000426971000011PubMedID: 29427602Scopus ID: 2-s2.0-85042173239OAI: oai:DiVA.org:miun-32815DiVA, id: diva2:1181326
Available from: 2018-02-08 Created: 2018-02-08 Last updated: 2018-04-03Bibliographically approved

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Hanstock, Helen

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