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Development of carboxymethyl cellulose-chitosan hybrid micro- and macroparticles for encapsulation of probiotic bacteria
CQC, University of Coimbra, Department of Chemistry, 3004-535 Coimbra, Portugal.
Faculty of Sciences and Technology (MeditBio), Ed. 8, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal.
CQC, University of Coimbra, Department of Chemistry, 3004-535 Coimbra, Portugal.
Faculty of Pharmacy and Center for Neurosciences and Cell Biology, University of Coimbra, Health Sciences Campus, 3000-5548 Coimbra, Portugal.
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2017 (English)In: Carbohydrate Polymers, ISSN 0144-8617, E-ISSN 1879-1344, Vol. 175, p. 87-95Article in journal (Refereed) Published
Abstract [en]

Novel carboxymethyl cellulose-chitosan (CMC-Cht) hybrid micro- and macroparticles were successfully prepared in aqueous media either by drop-wise addition or via nozzle-spray methods. The systems were either physically or chemically crosslinked using genipin as the reticulation agent. The macroparticles (ca. 2 mm) formed are found to be essentially of the core-shell type, while the microparticles (ca. 5 μm) are apparently homogeneous. The crosslinked particles are robust, thermally resistant and less sensitive to pH changes. On the other hand, the physical systems are pH sensitive presenting a remarkable swelling at pH 7.4, while little swelling is observed at pH 2.4. Furthermore, model probiotic bacteria (Lactobacillus rhamnosus GG) was for the first time successfully encapsulated in the CMC-Cht based particles with acceptable viability count. Overall, the systems developed are highly promising for probiotic encapsulation and potential delivery in the intestinal tract with the purpose of modulating gut microbiota and improving human health.

Place, publisher, year, edition, pages
2017. Vol. 175, p. 87-95
Keywords [en]
Carboxymethyl cellulose, Chitosan, Encapsulation, Genipin, Micro/macroparticles, Probiotic
National Category
Chemical Engineering
Identifiers
URN: urn:nbn:se:miun:diva-32183DOI: 10.1016/j.carbpol.2017.06.119ISI: 000411112500010PubMedID: 28917929Scopus ID: 2-s2.0-85026403113OAI: oai:DiVA.org:miun-32183DiVA, id: diva2:1161171
Available from: 2017-11-29 Created: 2017-11-29 Last updated: 2017-12-12Bibliographically approved

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Lindman, Björn

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