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Use of moist oral snuff (snus) and pancreatic cancer: Pooled analysis of nine prospective observational studies
Karolinska Inst, Stockholm.
Karolinska Inst, Stockholm; Stockholm City Council.
Karolinska Inst, Stockholm.
Karolinska Inst, Stockholm; Stockholm City Council.
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2017 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 141, no 4, 687-693 p.Article in journal (Refereed) Published
Abstract [en]

While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random effects at the study level, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for confounding factors. During 9,276,054 person-years of observation, 1,447 men developed pancreatic cancer. Compared to never-snus use, current snus use was not associated with risk of pancreatic cancer (HR 0.96, 95% CI 0.83-1.11) after adjustment for smoking. Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer. What's new? While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. Smokeless tobacco like snus yields lower exposure to tobacco carcinogens compared with smoking, because it does not undergo combustion, but delivers an equivalent dose of nicotine. Using pooled individual data from the Swedish Collaboration on Health Effects of Snus Use, here the authors show that Swedish snus use does not appear to be implicated in the development of pancreatic cancer in men. Tobacco smoke constituents other than nicotine or its metabolites may account for the relationship between smoking and pancreatic cancer.

Place, publisher, year, edition, pages
2017. Vol. 141, no 4, 687-693 p.
Keyword [en]
pancreatic cancer, incidence, snus
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:miun:diva-31346DOI: 10.1002/ijc.30773ISI: 000403795100006PubMedID: 28486772OAI: oai:DiVA.org:miun-31346DiVA: diva2:1130197
Available from: 2017-08-08 Created: 2017-08-08 Last updated: 2017-08-08Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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