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Epigenomic Diversity in a Global Collection of Arabidopsis thaliana Accessions
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2016 (English)In: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 166, no 2, 492-505 p.Article in journal (Refereed) Published
Abstract [en]

The epigenome orchestrates genome accessibility, functionality, and three-dimensional structure. Because epigenetic variation can impact transcription and thus phenotypes, it may contribute to adaptation. Here, we report 1,107 high-quality single-base resolution methylomes and 1,203 transcriptomes from the 1001 Genomes collection of Arabidopsis thaliana. Although the genetic basis of methylation variation is highly complex, geographic origin is a major predictor of genome-wide DNA methylation levels and of altered gene expression caused by epialleles. Comparison to cistrome and epicistrome datasets identifies associations between transcription factor binding sites, methylation, nucleotide variation, and co-expression modules. Physical maps for nine of the most diverse genomes reveal how transposons and other structural variants shape the epigenome, with dramatic effects on immunity genes. The 1001 Epigenomes Project provides a comprehensive resource for understanding how variation in DNA methylation contributes to molecular and non-molecular phenotypes in natural populations of the most studied model plant.

Place, publisher, year, edition, pages
Elsevier , 2016. Vol. 166, no 2, 492-505 p.
National Category
Natural Sciences
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URN: urn:nbn:se:miun:diva-30669DOI: 10.1016/j.cell.2016.06.044OAI: oai:DiVA.org:miun-30669DiVA: diva2:1091579
Available from: 2017-04-27 Created: 2017-04-27 Last updated: 2017-08-09Bibliographically approved

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Holm, Svante
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CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf