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In Vitro Assessment of Hydroxyapatite Coating on the Surface of Additive Manufactured Ti6Al4V Scaffolds
Tomsk Polytechnic University, Tomsk, Russia.
Tomsk Polytechnic University, Tomsk, Russia.
Mid Sweden University, Faculty of Science, Technology and Media, Department of Quality Technology and Management, Mechanical Engineering and Mathematics. (SportsTech Research Centre)ORCID iD: 0000-0003-2964-9500
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Puschino.
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2017 (English)In: Materials Science Forum, ISSN 0255-5476, E-ISSN 1662-9752, Vol. 879, 2444-2449 p.Article in journal (Refereed) Published
Abstract [en]

Custom orthopedic and dental implants may be fabricated by additive manufacturing (AM), for example using electron beam melting technology. This study is focused on the modification of the surface of Ti6Al4V alloy coin-like scaffolds fabricated via AM technology (EBM®) by radio frequency (RF) magnetron sputter deposition of hydroxyapatite (HA) coating. The scaffolds with HA coating were characterized by Scanning Electron microscopy, X-ray diffraction. HA coating showed a nanocrystalline structure with the crystallites of an average size of 32±9 nm. The ability of the surface to support adhesion and the proliferation of human mesenchymal stem cells was studied using biological short-term tests in vitro. In according to in vitro assessment, thin HA coating stimulated the attachment and proliferation of cells. Human mesenchymal stem cells cultured on the HA-coated scaffold also formed mineralized nodules.

Place, publisher, year, edition, pages
Switzerland: Trans Tech Publications Inc., 2017. Vol. 879, 2444-2449 p.
Keyword [en]
Additive Manufacturing, Electron Beam Melting (EBM), Hydroxyapatite, Magnetron Sputtering, Radio Frequency (RF)
National Category
Bio Materials Medical Biotechnology Manufacturing, Surface and Joining Technology
Identifiers
URN: urn:nbn:se:miun:diva-29480DOI: 10.4028/www.scientific.net/MSF.879.2444Scopus ID: 2-s2.0-85000399629OAI: oai:DiVA.org:miun-29480DiVA: diva2:1053065
Conference
9th International Conference on Processing and Manufacturing of Advanced Materials, THERMEC 2016; Graz; Austria; 29 May 2016 through 3 June 2016
Available from: 2016-12-08 Created: 2016-12-08 Last updated: 2017-11-29Bibliographically approved

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Koptyug, AndreySkoglund, Per

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