Mid Sweden University

miun.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls
Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden.
Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden.
Mid Sweden University, Faculty of Human Sciences, Department of Health Sciences. (Swedish Winter Sports Research Center)
Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci, Malmo, Sweden.
Show others and affiliations
2015 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 119, no 9, p. 953-960Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

Healthy first-degree relatives with heredity of type 2 diabetes (FH+) are known to have metabolic inflexibility compared with subjects without heredity for diabetes (FH-). In this study, we aimed to test the hypothesis that FH+ individuals have an impaired response to exercise compared with FH-. Sixteen FH+ and 19 FH- insulin-sensitive men similar in age, peak oxygen consumption ((V) over dot(O2 peak)), and body mass index completed an exercise intervention with heart rate monitored during exercise for 7 mo. Before and after the exercise intervention, the participants underwent a physical examination and tests for glucose tolerance and exercise capacity, and muscle biopsies were taken for expression analysis. The participants attended, on average, 39 training sessions during the intervention and spent 18.8 MJ on exercise. (V) over dot(O2 peak)/kg increased by 14%, and the participants lost 1.2 kg of weight and 3 cm waist circumference. Given that the FH- group expended 61% more energy during the intervention, we used regression analysis to analyze the response in the FH+ and FH- groups separately. Exercise volume had a significant effect on (V) over dot(O2 peak), weight, and waist circumference in the FH- group, but not in the FH+ group. After exercise, expression of genes involved in metabolism, oxidative phosphorylation, and cellular respiration increased more in the FH- compared with the FH+ group. This suggests that healthy, insulin-sensitive FH+ and FH- participants with similar age, (V) over dot(O2 peak), and body mass index may respond differently to an exercise intervention. The FH+ background might limit muscle adaptation to exercise, which may contribute to the increased susceptibility to type 2 diabetes in FH+ individuals.

Place, publisher, year, edition, pages
2015. Vol. 119, no 9, p. 953-960
Keywords [en]
type 2 diabetes, exercise intervention, expression analysis, genetic predisposition, muscle
National Category
Health Sciences Sport and Fitness Sciences
Identifiers
URN: urn:nbn:se:miun:diva-26513DOI: 10.1152/japplphysiol.01067.2014ISI: 000364478200001PubMedID: 26338460Scopus ID: 2-s2.0-84946104150OAI: oai:DiVA.org:miun-26513DiVA, id: diva2:882936
Available from: 2015-12-16 Created: 2015-12-16 Last updated: 2020-09-25Bibliographically approved

Open Access in DiVA

fulltext(408 kB)98 downloads
File information
File name FULLTEXT01.pdfFile size 408 kBChecksum SHA-512
899db7d5786eaaf8fda27e7df4959622afec0715d79b81a1c6ff3a3374a4300165cab904f36512549647be4daea8f04843664225ead12ee872336fce6d8625e5
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Ström, Kristoffer

Search in DiVA

By author/editor
Ström, Kristoffer
By organisation
Department of Health Sciences
In the same journal
Journal of applied physiology
Health SciencesSport and Fitness Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 98 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 104 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf