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RNA folding argues against a hot-start origin of life
Mittuniversitetet, Fakulteten för naturvetenskap, teknik och medier, Institutionen för teknik, fysik och matematik.
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2000 (Engelska)Ingår i: Journal of Molecular Evolution, ISSN 0022-2844, E-ISSN 1432-1432, Vol. 51, nr 4, s. 416-421Artikel i tidskrift (Övrigt vetenskapligt) Published
Abstract [en]

Opinion is strongly divided on whether life arose on earth under hot or cold conditions, the hot-start and cold-start Scenarios, respectively. The origin of life close to deep thermal vents appears as the majority opinion among biologists, but there is considerable biochemical evidence that high temperatures are incompatible with an RNA world. To be functional, RNA has to fold into a three-dimensional structure. We report both theoretical and experimental results on RNA folding and show that las expected) hot conditions strongly reduce RNA folding. The theoretical results come from energy-minimization calculations of the average extent of folding of RNA, mainly from 0-90 degreesC, for both random sequences and tRNA sequences. The experimental results are from circular-dichroism measurements of tRNA over a similar range of temperatures. The quantitative agreement between calculations and experiment is remarkable, even to the shape of the curves indicating the cooperative nature of RNA folding and unfolding. These results provide additional evidence for a lower temperature stage being necessary in the origin of life.

Ort, förlag, år, upplaga, sidor
2000. Vol. 51, nr 4, s. 416-421
Nyckelord [en]
circular dichroism, origin of life, RNA folding, RNA secondary, structure, RNA world, posttranscriptional modification, secondary structure, common ancestor, hyperthermophiles, eukaryotes, evolution, bacteria, tree
Nationell ämneskategori
Biokemi och molekylärbiologi
Identifikatorer
URN: urn:nbn:se:miun:diva-13717ISI: 000090055700012OAI: oai:DiVA.org:miun-13717DiVA, id: diva2:413251
Anmärkning
LetterTillgänglig från: 2011-04-28 Skapad: 2011-04-28 Senast uppdaterad: 2017-12-11Bibliografiskt granskad

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Moulton, Vincent

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Moulton, Vincent
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Institutionen för teknik, fysik och matematik
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Journal of Molecular Evolution
Biokemi och molekylärbiologi

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Totalt: 35 träffar
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